significant dose-response relationship emerging above roughly 150 IU/day, leading the authors to recommend that high-dosage Vitamin E be avoided. This is not a marginal caveat; it is a direct contradiction of the protective benefit that such products imply. The pattern extends well beyond a single nutrient. According to PubMed, a systematic review and meta-analysis spanning 884 randomized trials and more than 880,000 participants reported - KK, Mueen Ahmed (Free Radicals and Antioxidants, 2026)