Research ArticleAsian Journal of Biological and Life SciencesVol. 11 | Issue 1 | pp. 188–192Open access
GC-MS Profiling and in vitro Assessment of Antioxidant and Neuroprotective Properties of Ethanolic and Acetone Extracts of Oldenlandia corymbosa L.
- 1,
- 2*,
- 3,
- 4,
- 1
- 1 Vinayaka Mission’s College of Pharmacy, Vinayaka Mission Research Foundation (Deemed to be University), Ariyannur, Salem, Tamil Nadu, INDIA.
- 2 Department of Pharmacology, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission Research Foundation (Deemed to be University), Ariyannur, Salem, Tamil Nadu, INDIA.
- 3 Deputy Registrar (Invigilation), Sri Ramachandra institute of Higher Education and Research (D.U), Porur, Chennai, Tamil Nadu, INDIA.
- 4 Department of Pharmaceutical Chemistry, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission Research Foundation (Deemed to be university), Ariyannur, Salem, Tamil Nadu, INDIA.
Published in Asian Journal of Biological and Life Sciences
Correspondence: Gomathi Venkatachalam
Department of Pharmacology, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission Research Foundation (Deemed to be University), Ariyannur, Salem, Tamil Nadu, INDIA.
Email: mcbabith@gmail.com
- Received:
- Mar 16, 2022
- Accepted:
- Apr 6, 2022
- DOI:
- 10.5530/ajbls.2022.11.26
How to cite
Chellappan, B. M., Venkatachalam, G., Reddy, C. U., M, K., & BS, V. GC-MS Profiling and in vitro Assessment of Antioxidant and Neuroprotective Properties of Ethanolic and Acetone Extracts of Oldenlandia corymbosa L. Asian Journal of Biological and Life Sciences, 11(1), 188–192. https://doi.org/10.5530/ajbls.2022.11.26
Abstract
To investigate antioxidant and neuroprotective activity of ethanolic (OCWE) and acetone extract (OCWA) of Oldenlandia corymbosa plant and identification of phytochemical constituents present in both extracts by GC-MS analysis. The antioxidant potential of O. corymbosa was evaluated by DPPH and ABTS assays. MTT assay was used to test the plant’s neuroprotective effect on neuroblastoma cell lines. Phytoconstituents of said extracts have been quantified by GC-MS method. Ethanolic extract of plant showed lowest IC50 value (130.56μg/mL) compared to acetone extract (189.33μg/mL). More neuroprotective effect also exhibited by ethanolic extract. GC-MS analysis revealed the presence of numerous biologically active phytoconstituents in both extracts. On the basis of antioxidant and in-vitro neurotoxicity studies it is revealed that ethanolic extract of the plant showed more antioxidant and neuroprotective activity compared to the acetone extract and this may be due to the presence of antioxidant and anti-inflammatory fractions such as neophytadiene, squalene, stigmasterol and thunbergol.
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Article metadata
| Title | GC-MS Profiling and in vitro Assessment of Antioxidant and Neuroprotective Properties of Ethanolic and Acetone Extracts of Oldenlandia corymbosa L. |
|---|---|
| Authors | Babitha Mandapathil Chellappan; Gomathi Venkatachalam; Chakala Umamaheswara Reddy; Kumar M; Venketeswarawarlu BS |
| Affiliations | Vinayaka Mission’s College of Pharmacy, Vinayaka Mission Research Foundation (Deemed to be University), Ariyannur, Salem, Tamil Nadu, INDIA.; Department of Pharmacology, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission Research Foundation (Deemed to be University), Ariyannur, Salem, Tamil Nadu, INDIA.; Deputy Registrar (Invigilation), Sri Ramachandra institute of Higher Education and Research (D.U), Porur, Chennai, Tamil Nadu, INDIA.; Department of Pharmaceutical Chemistry, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission Research Foundation (Deemed to be university), Ariyannur, Salem, Tamil Nadu, INDIA. |
| Corresponding author | mcbabith@gmail.com |
| Journal | Asian Journal of Biological and Life Sciences |
| Volume / Issue | Vol. 11, Issue 1 |
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