Research ArticleBiology, Engineering, Medicine and Science ReportsVol. 6 | Issue 1 | pp. 9–10Open access
Pharmacology of Chloroquine: Potential Mechanism of Action against Coronavirus
- 1*
- 1 Veterinary Biosciences, School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, IRELAND.
Published in Biology, Engineering, Medicine and Science Reports
Correspondence: Arun HS Kumar
Veterinary Biosciences, School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, IRELAND.
Email: arun.kumar@ucd.ie
- Received:
- Feb 25, 2020
- Accepted:
- Mar 20, 2020
- DOI:
- 10.5530/bems.6.1.3
How to cite
Kumar, A. H. Pharmacology of Chloroquine: Potential Mechanism of Action against Coronavirus. Biology, Engineering, Medicine and Science Reports, 6(1), 9–10. https://doi.org/10.5530/bems.6.1.3
Abstract
Background: Chloroquine and hydroxychloroquine are recently reported to be effective in treating SARS-CoV-2 illness. The pharmacological mechanisms of this clinical benefit are continued to be explored. Materials and Methods: Using molecular docking tools in this study the binding affinity of Chloroquine and hydroxychloroquine were tested against two key SARS-CoV-2 targets i.e., 1) surface glycoprotein (6VSB) involved in viral attachment and 2) main protease (6Y84) involved in viral replication. Results: Chloroquine and hydroxy- chloroquine showed very effective binding affinity against both the SARS-CoV-2 targets. While the binding affinity against main protease was higher, multiple binding sites were observed on the surface glycoprotein of SARS-CoV-2. Conclusion: Chloroquine and hydroxy- chloroquinehave the potential to prevent SARS-CoV-2 attachment, entry and replication by directly binding to SARS-CoV-2 surface glycoprotein and its main protease.
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Article metadata
| Title | Pharmacology of Chloroquine: Potential Mechanism of Action against Coronavirus |
|---|---|
| Authors | Arun HS Kumar |
| Affiliations | Veterinary Biosciences, School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, IRELAND. |
| Corresponding author | arun.kumar@ucd.ie |
| Journal | Biology, Engineering, Medicine and Science Reports |
| Volume / Issue | Vol. 6, Issue 1 |
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