Gastroprotective agents use with Nonsteroidal Antiinflammatory Drugs: an Overview

Non-steroidal Anti-inflammatory Drugs (NSAIDs) are widely used in clinical set up for patient care because of their analgesic, anti-inflammatory and antipyretic properties. Most of the NSAIDs can cause gastrointestinal damage by inhibiting cyclooxygenase-1 (COX-1) enzyme. Strategies are recommended to reduce the risk of NSAIDs associated gastrointestinal (GI) adverse events. Prevention of GI morbidity induced by NSAIDs with co-prescription of Gastro protective agents (GPA) has been clinically approved. Administration of GPA in all NSAIDs users is unnecessary. Selection of GPA mainly depends upon the NSAID related GI risk and also the patient risk factor for GI complication as well as efficacy and tolerability of both NSAID and GPA.