Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 53 | Issue 4s | 2019 | pp. s548–s553Open access
Formulation and Development of Famotidine Solid Dispersion Tablets for their Solubility Enhancement
- 1*,
- 2,
- 1
- 1 University Institute of Chemical Technology (UICT), Kavayitri Bahinabai Chaudhari North Maharashtra University (KBCNMU), Jalgaon.
- 2 A.R. Ajmera College of Pharmacy, Nagaon, Dhule, Maharashtra, INDIA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Shirsath Nitin Rajendra
University Institute of Chemical Technology (UICT), Kavayitri Bahinabai Chaudhari North Maharashtra University (KBCNMU), Jalgaon.
Email: nitin.shirsath.5293@gmail.com
Copyright: © 2019 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2019
- Received:
- Jul 25, 2019
- Accepted:
- Oct 3, 2019
- DOI:
- 10.5530/ijper.53.4s.149
How to cite
Rajendra, S. N., Vaibhavkumar, J., & Kamalgiri, G. A. (2019). Formulation and Development of Famotidine Solid Dispersion Tablets for their Solubility Enhancement. Indian Journal of Pharmaceutical Education and Research, 53(4s), s548–s553. https://doi.org/10.5530/ijper.53.4s.149
Abstract
Background: Famotidine is BCS class II drug having a low aqueous solubility and low oral bioavailability. It needs to develop into its novel form for solubility and dissolution rate enhancement. Materials and Methods: The aim of the current work was to formulate famotidine (FAM)-poloxamer 188 solid dispersions (SDs) by kneading method for solubility enhancement. The problems of low solubility were eliminated by preparing the SDs using the poloxamer 188 as hydrophilic carrier. Results and Conclusion: The prepared tablets of SDs were characterized by employing solubility, FTIR, disintegration test, friability, wetting time and in-vitro drug release. The optimum values of solubility and in-vitro drug release of prepared novel formulation were maximum than conventional dosage form. The famotidine (FAM)-poloxamer 188 solid dispersions were successfully prepared and seem to be promising for enhanced dissolution rate (solubility) and oral bioavailability.
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Article metadata
| Title | Formulation and Development of Famotidine Solid Dispersion Tablets for their Solubility Enhancement |
|---|---|
| Authors | Shirsath Nitin Rajendra; Jagtap Vaibhavkumar; Goswami Ajaygiri Kamalgiri |
| Affiliations | University Institute of Chemical Technology (UICT), Kavayitri Bahinabai Chaudhari North Maharashtra University (KBCNMU), Jalgaon.; A.R. Ajmera College of Pharmacy, Nagaon, Dhule, Maharashtra, INDIA. |
| Corresponding author | nitin.shirsath.5293@gmail.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 53, Issue 4s (2019) |
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