Novel Chroman Analogs as Promising Heterocyclic Compounds: Their Synthesis and Antiepileptic Activity

Aim: New series of novel chroman analogs was designed and synthesized using appropriate synthetic route. Materials and Methods: Structures of synthesized chroman hydrazides fused with different anhydrides were supported by spectral data. After the neurotoxicity, assessed by rotarod motor impairment method, antiepileptic activities of twenty synthesized compounds were evaluated by both Pentylenetetrazole Seizure (PTZ) and Maximal electroshock seizure (MES) methods on mice. Administration at the suitable dose level of 30 mg/kg, 100 mg/kg and 300 mg/kg body weight of compounds and standards was done for PTZ and MES methods and for neurotoxicity. Results: Compound 5j (30 mg/kg) showed highest and advanced antiepileptic activity than reference drugs. None of the compounds showed neurotoxicity at 30 mg/kg and 100 mg/kg, as determined by the rotarod test. Whereas compounds 5m and 5p exhibited neurotoxicity at higher dose of 300 mg/kg after 4 hr. Conclusion: The results of the present study prove that the compounds have significant antiepileptic potential and are suitable candidates for further exploration.