Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 54 | Issue 3 | 2020 | pp. 618–629Open access
Development and Evaluation of Unidirectional Mucoadhesive Bio-Flexy Films Loaded with Nanosized Topiramate using a Novel Biopolymer from Glycine max
- 1*,
- 2
- 1 Kingston Imperial Institute of Technology and Sciences, Dehradun, Uttarakhand, INDIA.
- 2 Formulation Research Development, Vital Therapeutics and Formulations, Pvt. Ltd., Telangana, 500003, INDIA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Sugandha Varshney
Kingston Imperial Institute of Technology and Sciences, Dehradun, Uttarakhand, INDIA.
Email: sugandhavarshney19.12.86@gmail.com
Copyright: © 2020 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2020
- Received:
- Aug 3, 2019
- Accepted:
- Feb 26, 2020
- DOI:
- 10.5530/ijper.54.3.111
How to cite
Varshney, S., & Madhav, N. V. S. (2020). Development and Evaluation of Unidirectional Mucoadhesive Bio-Flexy Films Loaded with Nanosized Topiramate using a Novel Biopolymer from Glycine max. Indian Journal of Pharmaceutical Education and Research, 54(3), 618–629. https://doi.org/10.5530/ijper.54.3.111
Abstract
Aim: Formulation and evaluation of nanosized Topiramate loaded bio-flexy films using novel biopolymer isolated from Glycine max seeds for epilepsy treatment. Methods: Formulations containing nanosized Topiramate: Glycine max biopolymer (in ratios of 1:0.5, 1:1; 1:3, 1:5, 1:6, 1:10) (FGO1-FGO6) were prepared by solvent casting method. Results: Glycine max biopolymer showed percentage yield: 81.06%±0.01, light yellow, odorless, soluble in chloroform, water and color changing point: 218°C±2. Topiramate loaded bio-flexy films containing Glycine max biopolymer (FGO1-FGO6) revealed Thickness: 0.019 mm±0.012 to 0.037 mm±0.010, Surface pH:7.01±0.03 to 7.01±0.02, ex-vivo Mucoadhesion Time: 30-120 mins, ex vivo Mucoretention Time:90-210 mins, Weight Uniformity: 0.078±0.05 to 0.083±0.04, Drug Content Uniformity:72.7%±0.50 to 82.84%±0.48, Folding Endurance: 117-173, Swelling Percentage: 62%±0.6 to 74%±0.4, Percentage Moisture Uptake (PTU): 2.0%±0.13 to 2.8%±0.12. The drug release pattern based on the T50% and T80% was found to be FGO2 (1:1) > FGO6 (1:10) > FGO1 (1:0.5) > FGO4 (1:5)> FGO5 (1:6) > FGO3 (1:3). Conclusion: Based on all the evaluation parameters, FGO2 (containing Topiramate: Glycine max biopolymer (1:1)) Bio-flexy film having R2=0.9139, Higuchi Matrix as best fit model, follows Fickian Diffusion (Higuchi Matrix) release mechanism, T50%: 25 hr., T80%: 27 hr. Prepared formulations were suitable for Soft Palatal Delivery.
Keywords
Subject
Article metadata
| Title | Development and Evaluation of Unidirectional Mucoadhesive Bio-Flexy Films Loaded with Nanosized Topiramate using a Novel Biopolymer from Glycine max |
|---|---|
| Authors | Sugandha Varshney; N V Satheesh Madhav |
| Affiliations | Kingston Imperial Institute of Technology and Sciences, Dehradun, Uttarakhand, INDIA.; Formulation Research Development, Vital Therapeutics and Formulations, Pvt. Ltd., Telangana, 500003, INDIA. |
| Corresponding author | sugandhavarshney19.12.86@gmail.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 54, Issue 3 (2020) |
Also in this issue
- Is Covid-19 Sibling of SARS and MERS? A Review on: Novel Covid-19pp. 491–495
- Caspase Activators: Phytochemicals with Apoptotic Properties Targeting Cancer, a Health Care Strategy to Combat this Diseasepp. 496–508
- Therapeutic Potential of Chymase Inhibitors in Cardiovascular Diseases: An Overviewpp. 509–516
- Pharm D Program: Is it Necessary in BRICS?pp. 517–525
- Biomaterials in 3D Printing: A Special Emphasis on Nanocellulosepp. 526–540