Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 54 | Issue 3 | 2020 | pp. 826–834Open access
Fabrication of Poly (Sebacic acid-co-ricinoleic-ester anhydride) with β-cyclodextrin-loaded Doxorubicin Implants and in vitro Characterization
- 1,9*,
- 2,
- 1,
- 3,
- 4,
- 1,
- 1,
- 1,10,
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- 1 Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
- 2 Department of Pharmaceutics, PA College of Pharmacy, Mangalore, Karnataka, INDIA.
- 3 Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.
- 4 Department of Chemistry, College of Science, King Faisal University, Al-Ahsa, SAUDI ARABIA.
- 5 Department of Biomedical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
- 6 Department of Pharmacognosy, PA College of Pharmacy, Mangalore, Karnataka, INDIA.
- 7 School of Pharmacy, Monash University, Jalan Lagoon Selatan, Bandar Sunway, Selangor, MALAYSIA.
- 8 Department of Pharmacology, Faculty of Medicine, Minia University, El-Minia 61511, EGYPT.
- 9 Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, INDIA.
- 10 Department of Biotechnology and Food Technology, Durban University of Technology, Durban, SOUTH AFRICA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Nagaraja Sreeharsha
Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, INDIA.
Email: sharsha@kfu.edu.sa
Copyright: © 2020 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2020
- Received:
- Feb 29, 2020
- Accepted:
- Mar 30, 2020
- DOI:
- 10.5530/ijper.54.3.135
How to cite
Sreeharsha, N., Hiremath, J. G., Al-Dhubiab, B. E., Meravanige, G., Karnati, R. K., Attimarad, M., Nair, A. B., Venugopal, K. N., Morsy, M. A., Pottathil, S., Khan, S., & Molugulu, N. (2020). Fabrication of Poly (Sebacic acid-co-ricinoleic-ester anhydride) with β-cyclodextrin-loaded Doxorubicin Implants and in vitro Characterization. Indian Journal of Pharmaceutical Education and Research, 54(3), 826–834. https://doi.org/10.5530/ijper.54.3.135
Abstract
Background: Doxorubicin is an excellent molecule for the formation of biodegradable implants using the poly (sebacic acid-co-ricinoleic-ester anhydride) 70:30 w/w (poly[SARA] 70:30 w/w PSRA 7/3) polymer. Methods: The cylindrical implants were successfully produced by means of hot melt extrusion. We used differential scanning calorimetric (DSC) and X-ray diffraction (XRD) methods to identify the melting state and crystal type of blank and drug-loaded implants. A study was conducted on PSRA 7/3 w/w blank and drug-loaded implants for in vitro hydrolytic degradation. The drug present in the remaining sample was estimated. Results: The hydrolytic degradation rate of the 10% w/w (F2)-loaded implant was relatively low when compared with the 20% w/w (F3) implant. Discussion: In vitro drug release studies illustrated that the drug-release rate was faster in association with increasing amounts of doxorubicin in the implant.
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Article metadata
| Title | Fabrication of Poly (Sebacic acid-co-ricinoleic-ester anhydride) with β-cyclodextrin-loaded Doxorubicin Implants and in vitro Characterization |
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| Authors | Nagaraja Sreeharsha; Jagadeesh G Hiremath; Bandar E Al-Dhubiab; Girish Meravanige; Ranjith Kumar Karnati; Mahesh Attimarad; Anroop B Nair; Katharigatta N Venugopal; Mohamed A Morsy; Shinu Pottathil; Saleemmulla Khan; Nagashekhara Molugulu |
| Affiliations | Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Pharmaceutics, PA College of Pharmacy, Mangalore, Karnataka, INDIA.; Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Chemistry, College of Science, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Biomedical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Pharmacognosy, PA College of Pharmacy, Mangalore, Karnataka, INDIA.; School of Pharmacy, Monash University, Jalan Lagoon Selatan, Bandar Sunway, Selangor, MALAYSIA.; Department of Pharmacology, Faculty of Medicine, Minia University, El-Minia 61511, EGYPT.; Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, INDIA.; Department of Biotechnology and Food Technology, Durban University of Technology, Durban, SOUTH AFRICA. |
| Corresponding author | sharsha@kfu.edu.sa |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 54, Issue 3 (2020) |
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