Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 54 | Issue 3s | 2020 | pp. s512–s520Open access
Fabrication of Triprolidine∙HCl Transdermal Drug Delivery System and Pharmacokinetic Studies
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- 1 Department of Pharmacy Practice, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
- 2 Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.
- 3 Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
- 4 Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapur Road, Bangalore, INDIA.
- 5 Department of Pharmaceutics, PA College of Pharmacy, Mangalore, INDIA.
- 6 Department of Pharmaceutics, KLE University, Belgaum, Karnataka, INDIA.
- 7 Department of Chemistry, College of Science, King Faisal University, Hofuf, SAUDI ARABIA.
- 8 Department of Pharmacognosy PA College of Pharmacy, Mangalore, INDIA.
- 9 Department of Pharmaceutical Chemistry, PA College of Pharmacy, Mangalore, INDIA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Nagaraja Sreeharsha
Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapur Road, Bangalore, INDIA.
Email: sharsha@kfu.edu.sa
Copyright: © 2020 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2020
- Received:
- Jul 14, 2020
- Accepted:
- Sep 17, 2020
- DOI:
- 10.5530/ijper.54.3s.150
How to cite
Asif, A. H., Hodalur, N. P., Sreeharsha, N., Hiremath, J. G., Mistry, K. S., Al-Dhubiab, B. E., Meravanige, G., Karnati, R. K., Khan, S., Mubin, M., & Chathoth, A. T. (2020). Fabrication of Triprolidine∙HCl Transdermal Drug Delivery System and Pharmacokinetic Studies. Indian Journal of Pharmaceutical Education and Research, 54(3s), s512–s520. https://doi.org/10.5530/ijper.54.3s.150
Abstract
The purpose was to examine and analyze the matrix system of Triprolidine∙HCl wth the selected polymer ethyl cellulose. We achieved in vitro permeation studies using Keshary Chien diffusion cells across guinea pig skin. Considering the success of permeation enhancers with differing concentrations to enhance the permeation rate. The performed the in vitro dissolution of the developed transdermal patches. The in vivo analysis was carried out on male albino rabbits the drug release was determined by high performance liquid chromatography. The significant high performance liquid chromatography retention time of triprolidine∙HCl was 4.0 min. The limit of detection was 10 ng/mL and quantification limit of was 17 ng/ml. The area under curve was found to be 646.39 ng/ml.hr with the Kel was 0.0682 and Ka was 0.184 hour-1. The peak plasma concentration 24.54 ng/ml were produced in peak time of 8.58 hrs with the half life of 10.16 hrs.
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Article metadata
| Title | Fabrication of Triprolidine∙HCl Transdermal Drug Delivery System and Pharmacokinetic Studies |
|---|---|
| Authors | Afzal Haq Asif; Niranjan Puttaswamy Hodalur; Nagaraja Sreeharsha; Jagadeesh Gurupadayya Hiremath; Keyur Shileshbhai Mistry; Bandar E Al-Dhubiab; Girish Meravanige; Ranjith Kumar Karnati; Saleemulla Khan; Muhammed Mubin; Aiswarya Thelakkadan Chathoth |
| Affiliations | Department of Pharmacy Practice, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapur Road, Bangalore, INDIA.; Department of Pharmaceutics, PA College of Pharmacy, Mangalore, INDIA.; Department of Pharmaceutics, KLE University, Belgaum, Karnataka, INDIA.; Department of Chemistry, College of Science, King Faisal University, Hofuf, SAUDI ARABIA.; Department of Pharmacognosy PA College of Pharmacy, Mangalore, INDIA.; Department of Pharmaceutical Chemistry, PA College of Pharmacy, Mangalore, INDIA. |
| Corresponding author | sharsha@kfu.edu.sa |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 54, Issue 3s (2020) |
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