Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 54 | Issue 3s | 2020 | pp. s580–s585Open access
Clot Lysis Capacity of Andrographis paniculata and its Pure Compound Andrographolide
- 1,2*
- 1 Laboratory of Theoretical and Computational Biophysics, Ton Duc Thang University, Ho Chi Minh City, 700000, VIETNAM.
- 2 Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, 700000, VIETNAM.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Muhammad Torequl Islam
Laboratory of Theoretical and Computational Biophysics, Ton Duc Thang University, Ho Chi Minh City, 700000, VIETNAM.; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, 700000, VIETNAM.
Email: muhammad.torequl.islam@tdtu.edu.vn
Copyright: © 2020 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2020
- Received:
- Apr 19, 2020
- Accepted:
- Sep 7, 2020
- DOI:
- 10.5530/ijper.54.3s.157
How to cite
Islam, M. T. (2020). Clot Lysis Capacity of Andrographis paniculata and its Pure Compound Andrographolide. Indian Journal of Pharmaceutical Education and Research, 54(3s), s580–s585. https://doi.org/10.5530/ijper.54.3s.157
Abstract
Background: Andrographis paniculata and its main components andrographolide (AGL) have been reported for their promising cardio-protective effects in experimental animals. Aim: To investigate clot lysis activity of A. paniculata and AGL. Materials and Methods: The clot lysis activity of the aqueous A. paniculata stem extract (AAP) and AGL was investigated on clotted human blood by using streptokinase (SKE) as a standard drug. Results: Both AAP and AGL showed a concentration-dependent clot lysis activity. AAP showed the highest clot lysis activity at 100 μL (eq. 10% w/v) (54.12 ± 1.22%), while AGL showed at 100 μg/mL (58.62 ± 2.02%). The half maximal effective concentration (EC50) values of AAP and AGL were 87.32 ± 0.37 μL (eq. 8.732% w/v) and 79.74 ± 0.31 μg/mL, respectively. The netagive controls showed negligible clot lysis capacities, while the standard SKE showed 81.54 ± 0.78% clot lysis activity. Conclusion: AAP and its pure component NGL exhibited significant clot lysis activity on human clotted blood and may be good candidates for the treatment of atherothrombosis.
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Article metadata
| Title | Clot Lysis Capacity of Andrographis paniculata and its Pure Compound Andrographolide |
|---|---|
| Authors | Muhammad Torequl Islam |
| Affiliations | Laboratory of Theoretical and Computational Biophysics, Ton Duc Thang University, Ho Chi Minh City, 700000, VIETNAM.; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, 700000, VIETNAM. |
| Corresponding author | muhammad.torequl.islam@tdtu.edu.vn |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 54, Issue 3s (2020) |
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