Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 54 | Issue 4 | 2020 | pp. 1062–1071Open access
Xanthine Oxidase and Lipid Peroxidation Inhibition of Taiwan Folkloric Medicine Factors Affecting Rhus semialata var. Roxburghiana Activities against Xanthine Oxidase and Ferrous Iron-induced Lipid Peroxidation on Mice Liver Mitochondria
- 1,
- 2,
- 3,4,
- 5,6,
- 7*,
- 8,9,10*
- 1 Department of Medical Sciences Industry, College of Health Sciences, Chang Jung Christian University, Tainan, TAIWAN.
- 2 Department of Clinical Pathology, Far Eastern Memorial Hospital, New Taipei, TAIWAN.
- 3 School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, TAIWAN.
- 4 College of Acupuncture and Oriental Medicine, Houston, Texas, USA.
- 5 Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, TAIWAN.
- 6 Department of Biomedical Engineering, National Defense Medical Center, Taipei, TAIWAN.
- 7 Department of Chemistry, Tamkang University, New Taipei City, TAIWAN.
- 8 Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, TAIWAN.
- 9 School of Medicine, College of Medicine, Taipei Medical University, Taipei, TAIWAN.
- 10 School of Medicine Integrative Therapy Center for Gastroenterologic Cancers, Wan Fang Hospital, Taipei Medical University, Taipei, TAIWAN.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Bo-Cheng Wang
Department of Chemistry, Tamkang University, New Taipei City, TAIWAN.
Email: vw1017@gmail.com
Copyright: © 2020 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2020
- Received:
- Jun 12, 2020
- Accepted:
- Sep 17, 2020
- DOI:
- 10.5530/ijper.54.4.201
How to cite
Tsai, P. W., Lin, P. C., Yang, L. L., Liao, A. H., Wang, B. C., & Wu, M. S. (2020). Xanthine Oxidase and Lipid Peroxidation Inhibition of Taiwan Folkloric Medicine Factors Affecting Rhus semialata var. Roxburghiana Activities against Xanthine Oxidase and Ferrous Iron-induced Lipid Peroxidation on Mice Liver Mitochondria. Indian Journal of Pharmaceutical Education and Research, 54(4), 1062–1071. https://doi.org/10.5530/ijper.54.4.201
Abstract
Background: Gout, a disease characterized by recurrent inflammatory for urate deposit from overactive xanthine oxidase, is common among Taiwanese. Rhus semialata var. roxburghiana (RSR) grows wildly in Central Mountain of Taiwan and used by aboriginal Taiwanese as traditional medicine for gout and hepatitis. Methods: In this study, the factors such as variations in RSR extracts in terms of geographical sources, aerial parts and extraction solvents were investigated for antioxidant capabilities, phytochemical analysis and inhibitory effects against xanthine oxidase and lipid peroxidation using ferrous ion as ROS inducer on mice liver mitochondria. Results: The results showed that ML-n-hexane and NS-acetone gave the maximum XO inhibitions (IC50=16.74±0.74 μg/mL) and LPO inhibitions (IC50=8.40±0.35 μg/mL) in the liver mitochondria of mice, respectively. And ML-n-hexane and NS-acetone contained phenolic and flavonoids compounds for its potential target components against XO and LPO in this study. Conclusion: Overall, RSR could lead to a medicinal potential as a suitable candidate for the development of a natural anti-gout and liver damage protective agent that have yet to be conducted.
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Article metadata
| Title | Xanthine Oxidase and Lipid Peroxidation Inhibition of Taiwan Folkloric Medicine Factors Affecting Rhus semialata var. Roxburghiana Activities against Xanthine Oxidase and Ferrous Iron-induced Lipid Peroxidation on Mice Liver Mitochondria |
|---|---|
| Authors | Po-Wei Tsai; Pei-Chin Lin; Ling-Ling Yang; Ai-Ho Liao; Bo-Cheng Wang; Ming-Shun Wu |
| Affiliations | Department of Medical Sciences Industry, College of Health Sciences, Chang Jung Christian University, Tainan, TAIWAN.; Department of Clinical Pathology, Far Eastern Memorial Hospital, New Taipei, TAIWAN.; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, TAIWAN.; College of Acupuncture and Oriental Medicine, Houston, Texas, USA.; Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, TAIWAN.; Department of Biomedical Engineering, National Defense Medical Center, Taipei, TAIWAN.; Department of Chemistry, Tamkang University, New Taipei City, TAIWAN.; Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, TAIWAN.; School of Medicine, College of Medicine, Taipei Medical University, Taipei, TAIWAN.; School of Medicine Integrative Therapy Center for Gastroenterologic Cancers, Wan Fang Hospital, Taipei Medical University, Taipei, TAIWAN. |
| Corresponding author | vw1017@gmail.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 54, Issue 4 (2020) |
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