Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 54 | Issue 4 | 2020 | pp. 1089–1097Open access
Neuroprotective effect of 1, 3-β-glucan-curcumin mixing (Bioglucur) on Alzheimer Disease Induced in Mice by Aluminium Toxicity
- 1,
- 1*,
- 2,
- 2,
- 2,
- 3,4
- 1 Laboratory of Pharmacognosy and Api Phytotherapy, University of Mostaganem, Mostaganem, ALGERIA.
- 2 Institute of Natural Products Chemistry (INPC), Vietnam Academy of Science and Technology (VAST), Hoang Quoc Viet, Caugiay, Hanoi, VIETNAM.
- 3 Institute of Theoretical and Applied Research, Duy Tan University, Hanoi, VIETNAM.
- 4 Institute of Physics (IOP), Vietnam Academy of Science and technology (VAST), Dao Tan, Ba Dinh, Hanoi, VIETNAM.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Noureddine Djebli
Laboratory of Pharmacognosy and Api Phytotherapy, University of Mostaganem, Mostaganem, ALGERIA.
Email: noureddine.djebli27@gmail.com
Copyright: © 2020 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2020
- Received:
- May 6, 2020
- Accepted:
- Sep 23, 2020
- DOI:
- 10.5530/ijper.54.4.204
How to cite
Amari, N. O., Djebli, N., Huong, L. M., Ha, T. T. H., Luyen, N. D., & Bich, V. T. (2020). Neuroprotective effect of 1, 3-β-glucan-curcumin mixing (Bioglucur) on Alzheimer Disease Induced in Mice by Aluminium Toxicity. Indian Journal of Pharmaceutical Education and Research, 54(4), 1089–1097. https://doi.org/10.5530/ijper.54.4.204
Abstract
Aim: The aim of this study was to evaluate the neuroprotective effect of oral administration of acomplex of curcumin with 1,3-β-glucan extracted from Vietnamese mushrooms named Bioglucur to increase drug delivery efficiency and biological effectin Alzheimer’s model mice. Materials and Methods: Alzheimer’s disease was induced in mice and treated in parallel by Bioglucur. Results: Results obtained show that the Bioglucur improves impart mental concentration and memory and decrease anxiety thus the storage capacity is improved during the Morris test and even neurons improvement in the histological study in treated mice. Conclusion: The mixture preparation of curcumin and 1,3-β-glucans from Vietnamese medicinal mushrooms increase the bioavibility of curcumin and helps recover neurons in mice Alzheimer’s model.
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Article metadata
| Title | Neuroprotective effect of 1, 3-β-glucan-curcumin mixing (Bioglucur) on Alzheimer Disease Induced in Mice by Aluminium Toxicity |
|---|---|
| Authors | Nesrine Ouda Amari; Noureddine Djebli; Le Mai Huong; Tran Thi Hong Ha; Nguyen Dinh Luyen; Vu Thi Bich |
| Affiliations | Laboratory of Pharmacognosy and Api Phytotherapy, University of Mostaganem, Mostaganem, ALGERIA.; Institute of Natural Products Chemistry (INPC), Vietnam Academy of Science and Technology (VAST), Hoang Quoc Viet, Caugiay, Hanoi, VIETNAM.; Institute of Theoretical and Applied Research, Duy Tan University, Hanoi, VIETNAM.; Institute of Physics (IOP), Vietnam Academy of Science and technology (VAST), Dao Tan, Ba Dinh, Hanoi, VIETNAM. |
| Corresponding author | noureddine.djebli27@gmail.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 54, Issue 4 (2020) |
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