Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 55 | Issue 2 | 2021 | pp. 363–373Open access
Synthesis, Characterization and Pharmacological Evaluation of Biphenyl Based 4-Thiazolidinones
- 1,
- 1,
- 2,
- 2*
- 1 Department of Pharmaceutical Chemistry, Vivekanand Education Society College of Pharmacy, Chembur, Mumbai, Maharashtra, INDIA.
- 2 Department of Pharmaceutical Chemistry, DY Patil University School of Pharmacy, Affiliated to DY Patil (Deemed to be University), Nerul, Navi Mumbai, Maharashtra, INDIA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Rakesh Somani
Department of Pharmaceutical Chemistry, DY Patil University School of Pharmacy, Affiliated to DY Patil (Deemed to be University), Nerul, Navi Mumbai, Maharashtra, INDIA.
Email: rakeshrsomani@gmail.com
Copyright: © 2021 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2021
- Received:
- Jun 10, 2020
- Accepted:
- Mar 13, 2021
- DOI:
- 10.5530/ijper.55.2.74
How to cite
Shirke, M., Gangthade, M., Chaskar, P., & Somani, R. (2021). Synthesis, Characterization and Pharmacological Evaluation of Biphenyl Based 4-Thiazolidinones. Indian Journal of Pharmaceutical Education and Research, 55(2), 363–373. https://doi.org/10.5530/ijper.55.2.74
Abstract
Background: Biphenyl based 4-thiazolidinones are found to possess a wide range of activities resulting in their synthesis. Methods: Eight molecules (VIIa-VIIh) were profoundly synthesized using four step procedures. These 4-thiazolidinone derivatives were characterized by elemental analysis (CHN) and spectral (IR and 1H NMR) analysis. All the compounds were evaluated for their in vitro antimicrobial activity against one Gram negative strain (Escherichia coli) and two Gram positive strains (Bacillus subtilis and Staphylococcus aureus) and two fungal strains (Candida albicans and Aspergillus niger). Results: The results of antimicrobial studies revealed that compounds (VIIg) possessed moderate antifungal activity and compounds (VIIc and VIIe) showed good antibacterial activity against fungal and bacterial strain respectively. Conclusion: Compounds containing electron withdrawing groups (-NO2, -CI, -Br) on the aromatic ring showed improved antimicrobial activity.
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Article metadata
| Title | Synthesis, Characterization and Pharmacological Evaluation of Biphenyl Based 4-Thiazolidinones |
|---|---|
| Authors | Monika Shirke; Monali Gangthade; Pratip Chaskar; Rakesh Somani |
| Affiliations | Department of Pharmaceutical Chemistry, Vivekanand Education Society College of Pharmacy, Chembur, Mumbai, Maharashtra, INDIA.; Department of Pharmaceutical Chemistry, DY Patil University School of Pharmacy, Affiliated to DY Patil (Deemed to be University), Nerul, Navi Mumbai, Maharashtra, INDIA. |
| Corresponding author | rakeshrsomani@gmail.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 55, Issue 2 (2021) |
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