Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 56 | Issue 2 | 2022 | pp. 414–419Open access
Formulation and Evaluation of Bendamustine Loaded Polymeric Nanoparticle
- 1*,
- 2*,
- 3,
- 4,
- 5,
- 6,
- 7,
- 8,
- 9,10,
- 11
- 1 Department of Surgery, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.
- 2 Department of Pharmaceutics, IKON Pharmacy College, Bidadi, Karnataka, INDIA.
- 3 Department of Pharmaceutics, College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, Karnataka, INDIA.
- 4 Department of Pharmaceutics, Oxbridge College of Pharmacy, Bengaluru, Karnataka, INDIA.
- 5 Department of Pharmacology, Oxbridge College of Pharmacy, Bengaluru, Karnataka, INDIA.
- 6 Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.
- 7 Department of Pharmacy Practice, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
- 8 Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Dariyah, Riyadh, SAUDI ARABIA.
- 9 Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Hofuf, Al-Ahsa, SAUDI ARABIA.
- 10 Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, INDIA.
- 11 Department of Pharmacognosy, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, INDIA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Mallikarjun Telsang
Department of Surgery, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.
Email: mvtelsang@kfu.edu.sa
Copyright: © 2022 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2022
- Received:
- Oct 4, 2021
- Accepted:
- Feb 23, 2022
- DOI:
- 10.5530/ijper.56.2.61
How to cite
Telsang, M., D, P., B, W., Tamreen, V., Sadik, S., Habeebuddin, M., Asif, A. H., Asdaq, M. B., Nagaraja, S. H., & Noor, S. D. (2022). Formulation and Evaluation of Bendamustine Loaded Polymeric Nanoparticle. Indian Journal of Pharmaceutical Education and Research, 56(2), 414–419. https://doi.org/10.5530/ijper.56.2.61
Abstract
Background: Bendamustine-loaded albumin nanoparticles were prepared using different concentrations of Bovine Serum Albumin (BSA) with the goal of delivering the medication to particular cancer cells. Materials and Procedures: The nanoparticles were prepared using simple coacervation technique with increasing concentrations of BSA. The nanoparticles were characterized for process yield, particle size, surface morphology, drug loading capacity (%), particle size distribution (Polydispersity index), in-vitro drug release. The drug release kinetics were studies using different dissolution models. The drug loading capacity of the produced nanoparticles varied from 10.4% to 19%. Formulation (F1) had a mean particle size of approximately 122.4 nm and polydispersivity index of 0.432 across the different compositions. Bendamustine nanoparticles exhibit sustained drug release with almost 51.8% bendamustine released in one day. The drug release kinetics follows Korsmeyer-Peppas model with a Fickian drug release mechanism. The Bendamustine nanoparticles were found to be stable for a month at 40±5C and 75±5% relative humidity. Conclusion: Bendamustine loaded BSA nanoparticles were developed which were found to exhibit a sustained drug release profile. Albumin based Bendamustine nanoparticles have the potential to be explored further for the better management of the cancer chemotherapy with reduced side effects.
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Article metadata
| Title | Formulation and Evaluation of Bendamustine Loaded Polymeric Nanoparticle |
|---|---|
| Authors | Mallikarjun Telsang; Pradeep D; Wilson B; Vasia Tamreen; Shaik Sadik; Mohammed Habeebuddin; Afzal Haq Asif; Mohammed Basheeruddin Asdaq; Sree Harsha Nagaraja; Syed Dawood Noor |
| Affiliations | Department of Surgery, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Pharmaceutics, IKON Pharmacy College, Bidadi, Karnataka, INDIA.; Department of Pharmaceutics, College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, Karnataka, INDIA.; Department of Pharmaceutics, Oxbridge College of Pharmacy, Bengaluru, Karnataka, INDIA.; Department of Pharmacology, Oxbridge College of Pharmacy, Bengaluru, Karnataka, INDIA.; Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Pharmacy Practice, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Dariyah, Riyadh, SAUDI ARABIA.; Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Hofuf, Al-Ahsa, SAUDI ARABIA.; Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, INDIA.; Department of Pharmacognosy, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, INDIA. |
| Corresponding author | mvtelsang@kfu.edu.sa |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 56, Issue 2 (2022) |
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