Novel Formulation for Facial Acne using Liposomal Gel Containing Lipid Soluble Naphthoic Acid Derivative

The first line therapies in many acne diagnoses include application of retinoic acid derivatives for improvement in acne severity. Though, it has been observed that, current available formulations are sensitive to skin and requires to be applied after repeated time to prolong the action of the medicament at the local layers. To overcome this major downside, in the present investigation the Adapalene (AD) being entrapped into the lipid layers of the liposomes (LUVs) to provide the sustain release and also to bypass the main adverse effect of the retinoic acid derivatives of being toxic if absorbed into blood stream. Aim: To prepare and evaluate the liposomal adapalene for sustain release effect and entrapment into skin layers. Materials and Methods: To prepare the LUVs by film hydration method various lipid polymers are being utilised like DMPG, DPPG, HSPC, and cholesterol. Prepared LUVs were optimized on the basis of particle size, entrapment efficiency. The batch with highest entrapment efficiency (66.18%) and particle size range of 1000nm was further incorporated into (5%) HPMCk4M gel to avail the application compliance in the patient. This formulation was studied for viscosity, pH, Drug content, Spreadability study, in vitro drug release pattern of the dosage form, exvivo skin retention study in the layers of skin. Results: The result of the in-vitro release study showed only 28% of drug release which is beneficial for follicular delivery as well as sustained release of the AD. Conclusion: This can be concluding that, AD liposomal gel can be potential solution to the adverse reaction of the current marketed formulation with insights of providing low frequency of application and improved skin health in the acne prone patients.