Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 57 | Issue 2 | 2023 | pp. 459–465Open access
Chemical Composition, Antioxidant and Anti-tumor Activities of the Aerial Parts of Cometes abyssinica R.Br. ex Wall
- 1,2*
- 1 Department of Medicinal and Aromatic Plants, Desert Research Center, Cairo, EGYPT.
- 2 Department of Chemistry, Faculty of Science, Jazan University, Jizan, SAUDI ARABIA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Ahmed AM Abdelgawad
Department of Medicinal and Aromatic Plants, Desert Research Center, Cairo, EGYPT.; Department of Chemistry, Faculty of Science, Jazan University, Jizan, SAUDI ARABIA.
Email: ahmedawad26@hotmail.com
Copyright: © 2023 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2023
- Received:
- Mar 25, 2022
- Accepted:
- Feb 6, 2023
- DOI:
- 10.5530/ijper.57.2.56
How to cite
Abdelgawad, A. A. (2023). Chemical Composition, Antioxidant and Anti-tumor Activities of the Aerial Parts of Cometes abyssinica R.Br. ex Wall. Indian Journal of Pharmaceutical Education and Research, 57(2), 459–465. https://doi.org/10.5530/ijper.57.2.56
Abstract
An in vitro bioassay-guide revealed that the methanolic extract of the aerial parts of Cometes abyssinica had considerable inhibitory activity against colon (HCT-116) and hepatocellular (HepG2) carcinoma cell lines with IC50 24.4 and 29.9 μg/mL, respectively, compared to the drug reference Cisplatin. On the other hand, all studied extracts exhibited weak antioxidant activities using the DPPH scavenging assay with IC50 values between 543-826.4 μg/mL. Phytochemical investigation of the methanol and ethyl acetate extracts of C. abyssinica led to the isolation of five flavonoid compounds: Formononetin 1, Daidzein 2, Eriodictyol 3, Taxifolin 4, and kaempferitrin 5. The chemical structure of the isolated compounds was identified based on their physicochemical and spectroscopic analyses.
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Article metadata
| Title | Chemical Composition, Antioxidant and Anti-tumor Activities of the Aerial Parts of Cometes abyssinica R.Br. ex Wall |
|---|---|
| Authors | Ahmed AM Abdelgawad |
| Affiliations | Department of Medicinal and Aromatic Plants, Desert Research Center, Cairo, EGYPT.; Department of Chemistry, Faculty of Science, Jazan University, Jizan, SAUDI ARABIA. |
| Corresponding author | ahmedawad26@hotmail.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 57, Issue 2 (2023) |
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