Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 57 | Issue 3s | 2023 | pp. s690–s700Open access
Syringodium isoetifolium Fosters an Antioxidant Defense System, Modulates Glycolytic Enzymes and Protects Membrane Integrity in DEN-induced Hepatocellular Carcinoma in Albino Wistar Rats
- 1,2,
- 1*,
- 2,
- 2,
- 2,
- 2
- 1 Department of Biochemistry, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, Tamil Nadu, INDIA.
- 2 Department of Pharmaceutical Chemistry, GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, INDIA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Ramakrishnan Padmini
Department of Biochemistry, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, Tamil Nadu, INDIA.
Email: padmini.sls@velsuniv.ac.in
Copyright: © 2023 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2023
- Received:
- Sep 27, 2022
- Accepted:
- Jun 15, 2023
- DOI:
- 10.5530/ijper.57.3s.78
How to cite
Kavitha, D., Padmini, R., Dhanaraju, M. D., Gopi, C., Thiyagarajan, D., & Veeramaneni, A. (2023). Syringodium isoetifolium Fosters an Antioxidant Defense System, Modulates Glycolytic Enzymes and Protects Membrane Integrity in DEN-induced Hepatocellular Carcinoma in Albino Wistar Rats. Indian Journal of Pharmaceutical Education and Research, 57(3s), s690–s700. https://doi.org/10.5530/ijper.57.3s.78
Abstract
Background: Syringodium isoetifolium seagrass has bioactive constituents with potential pharmacological uses, but their use is limited. Materials and methods: Wistar albino rats were split into five groups. Except for group I, remaining all received DEN and Phenobarbitone. Extracts were administered to group III and IV orally with the dose of 250 and 500 mg/kg. 5 fluorouracil 20mg/kg was the standard. Results: The findings show that Syringodium isoetifolium significantly reduces liver tumor volume, burden and numbers in experimental rats (p less than 0.05). Besides, the extracts treated groups restored the pathological parameters close to normal values. Conclusion: The study concludes that Syringodium isoetifolium inhibits cancer growth by altering the antioxidant defense system, glycolysis and protecting membrane architecture.
Keywords
Article metadata
| Title | Syringodium isoetifolium Fosters an Antioxidant Defense System, Modulates Glycolytic Enzymes and Protects Membrane Integrity in DEN-induced Hepatocellular Carcinoma in Albino Wistar Rats |
|---|---|
| Authors | Dhanaraju Kavitha; Ramakrishnan Padmini; Magharla Dasaratha Dhanaraju; Chandravadivelu Gopi; Deepan Thiyagarajan; Alekkhya Veeramaneni |
| Affiliations | Department of Biochemistry, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, Tamil Nadu, INDIA.; Department of Pharmaceutical Chemistry, GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, INDIA. |
| Corresponding author | padmini.sls@velsuniv.ac.in |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 57, Issue 3s (2023) |
Also in this issue
- Herbal Nanoparticles: A Commitment towards Contemporary Approachpp. s465–s480
- Nanoemulgel: A Smarter Topical Lipidic Emulsion-based Nanocarrierpp. s481–s498
- Analyzing Biosimilars in Brazil: Comprehensive Specifications of the Regulatory Systempp. s499–s506
- An Analysis of the Extent of Intra and Inter-rater Variability in OSCEpp. s507–s510
- Enhancement of the Solubility of Lipophilic Drug by Self-Micro Emulsifying Drug Delivery System (SMEDDS) For Oral Administrationpp. s511–s519