Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 57 | Issue 3s | 2023 | pp. s701–s709Open access
Brassinin Exhibits Anti-Diabetic Activity against Streptozotocin-induced Diabetes Mellitus in Experimental Rats
- 1*,
- 2,
- 2,
- 3,
- 4,
- 5
- 1 Teaching and Research Section of Internal Medicine, Zhaoqing Medical College, Guangdong Province, CHINA.
- 2 Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, SAUDI ARABIA.
- 3 Department of Cellular and Molecular Biology, University of Texas at Tyler Health Science Center, Tyler, TEXAS, USA.
- 4 Faculty of Medicine, Bioscience and Nursing, Mahsa University, Saujana Putra, MALAYSIA.
- 5 Department of Chemistry, Faculty of Science, Isra University, Amman, JORDAN.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Bixia Xu
Teaching and Research Section of Internal Medicine, Zhaoqing Medical College, Guangdong Province, CHINA.
Email: surither@hotmail.com
Copyright: © 2023 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2023
- Received:
- Jan 1, 2023
- Accepted:
- Jul 1, 2023
- DOI:
- 10.5530/ijper.57.3s.79
How to cite
Xu, B., Alarfaj, A. A., Hirad, A. H., Natarajan, N., Iyappan, P., & Ali, S. H. H. A. (2023). Brassinin Exhibits Anti-Diabetic Activity against Streptozotocin-induced Diabetes Mellitus in Experimental Rats. Indian Journal of Pharmaceutical Education and Research, 57(3s), s701–s709. https://doi.org/10.5530/ijper.57.3s.79
Abstract
Background: Diabetes mellitus is among the most serious public health problems worldwide. Materials and Methods: 35mg/kg STZ was injected to rats for stimulating diabetes. Then rats were treated with 25mg/kg of brassinin. Results: Brassinin and Glibenclamide remarkably decreased glucose and HbA1c levels in diabetic rats, while insulin levels were elevated. They also increased antioxidant enzymes and decreased inflammatory markers. Conclusion: Brassinin is an antihyperglycemic, antioxidant, and anti-inflammatory compound that protects the liver, kidney, and pancreas during diabetes.
Keywords
Article metadata
| Title | Brassinin Exhibits Anti-Diabetic Activity against Streptozotocin-induced Diabetes Mellitus in Experimental Rats |
|---|---|
| Authors | Bixia Xu; Abdullah A. Alarfaj; Abdurahman Hajinur Hirad; Nandakumar Natarajan; Petchi Iyappan; Samer Hasan Hussein Al Ali |
| Affiliations | Teaching and Research Section of Internal Medicine, Zhaoqing Medical College, Guangdong Province, CHINA.; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, SAUDI ARABIA.; Department of Cellular and Molecular Biology, University of Texas at Tyler Health Science Center, Tyler, TEXAS, USA.; Faculty of Medicine, Bioscience and Nursing, Mahsa University, Saujana Putra, MALAYSIA.; Department of Chemistry, Faculty of Science, Isra University, Amman, JORDAN. |
| Corresponding author | surither@hotmail.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 57, Issue 3s (2023) |
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