Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 58 | Issue 1 | 2024 | pp. 198–203Open access
Histopathological and Biochemical Investigation of the Effect of Shepherd's Purse (Capsella bursa-pastoris L.) on Ethanol-Induced Liver Damage
- 1,
- 2*,
- 3
- 1 Vocational School of Health Services, Gaziantep İslam Bilim ve Teknoloji University, Gaziantep, TURKEY.
- 2 Department of Pathology, Faculty of Veterinary Medicine, Van Yuzuncu Yil University, Van, TURKEY.
- 3 Vocational School of Health Services, Van Yuzuncu Yil University, Van, TURKEY.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Turan Yaman
Department of Pathology, Faculty of Veterinary Medicine, Van Yuzuncu Yil University, Van, TURKEY.
Email: turanyaman@yyu.edu.tr
Copyright: © 2024 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2024
- Received:
- Aug 25, 2022
- Accepted:
- Aug 14, 2023
- DOI:
- 10.5530/ijper.58.1.21
How to cite
Polat, O., Yaman, T., & Kömüroğlu, A. U. (2024). Histopathological and Biochemical Investigation of the Effect of Shepherd's Purse (Capsella bursa-pastoris L.) on Ethanol-Induced Liver Damage. Indian Journal of Pharmaceutical Education and Research, 58(1), 198–203. https://doi.org/10.5530/ijper.58.1.21
Abstract
Background: The aim of the present study was to investigate the hepatoprotective effect of Shepherd's Purse (SP) herbal tea on ethanol (EtOH)-induced liver toxicity. Materials and Methods: Male Wistar rats (n = 32) were divided into 4 experimental groups: control, EtOH (30% EtOH), EtOH+SP (30% EtOH+1 mL/kg SP), and SP (1 mL/kg SP orally). EtOH and SP were administered by orogastric gavage once daily. At the end of the 60-day experimental period, tissue and blood samples were obtained from the rats following necropsy. Results: Histopathologically, degenerative-necrotic changes in the liver of the EtOH group rats were partially reduced in the SP treatment group. Biochemical examinations revealed that SP treatment decreased aspartic transaminase, alanine transaminase, and alkaline phosphatase levels in the SP-treated rats compared to the EtOH group rats. While SP treatment had a positive effect on the triglyceride and HDL levels, it had a negative effect on the LDL and cholesterol levels. Conclusion: Consequently, it was determined that SP tea provides partial protection against EtOH-induced liver toxicity
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Article metadata
| Title | Histopathological and Biochemical Investigation of the Effect of Shepherd's Purse (Capsella bursa-pastoris L.) on Ethanol-Induced Liver Damage |
|---|---|
| Authors | Orhan Polat; Turan Yaman; Ahmet Ufuk Kömüroğlu |
| Affiliations | Vocational School of Health Services, Gaziantep İslam Bilim ve Teknoloji University, Gaziantep, TURKEY.; Department of Pathology, Faculty of Veterinary Medicine, Van Yuzuncu Yil University, Van, TURKEY.; Vocational School of Health Services, Van Yuzuncu Yil University, Van, TURKEY. |
| Corresponding author | turanyaman@yyu.edu.tr |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 58, Issue 1 (2024) |
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