Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 58 | Issue 1s | 2024 | pp. s214–s220Open access
In vitro Evaluation of Curcumin and Quercetin in Combination on Oxidative Stress
- 1,2,
- 3,
- 4*,
- 5,
- 3,
- 6
- 1 Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, INDIA
- 2 Department of Pharmaceutics, College of Pharmacy, JSS Academy of Technical Education, Noida, Uttar Pradesh, INDIA
- 3 Department of Pharmacognosy, College of Pharmacy, JSS Academy of Technical Education, Noida, Uttar Pradesh, INDIA
- 4 Centre for Drug Regulatory Affairs and Pharmacy Practice, Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, INDIA
- 5 Department of Pharmaceutical Chemistry, College of Pharmacy, JSS Academy of Technical Education, Noida, Uttar Pradesh, INDIA
- 6 Department of Pharmaceutical Biotechnology, JSS College of Pharmacy, Ooty, JSS Academy of Higher Education and Research, Myore, INDIA
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Vikesh Kumar Shukla
Centre for Drug Regulatory Affairs and Pharmacy Practice, Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, INDIA
Email: vkshukla@amity.edu
Copyright: © 2024 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2024
- Received:
- Jun 21, 2023
- Accepted:
- Aug 22, 2024
- DOI:
- 10.5530/ijper.20254445
How to cite
Katrolia, A., Vedpal, Shukla, V. K., Singh, R., Chandra, S., & Raman, R. (2024). In vitro Evaluation of Curcumin and Quercetin in Combination on Oxidative Stress. Indian Journal of Pharmaceutical Education and Research, 58(1s), s214–s220. https://doi.org/10.5530/ijper.20254445
Abstract
Background
Flavonoids are the natural product belongs to an important class of plant secondary metabolites. They are polyphenolic compounds and known for decades as a potent natural antioxidant. Curcumin (flavonoid polyphenol) and quercetin (flavonol) both are popular natural antioxidants and contributes a major role as an individual in the treatment of oxidative stress. This research study is more focused in their combination effect against oxidative stress.
Materials and Methods
In this present research, we focused on hydro-alcoholic maceration of Curcuma longa rhizomes and Morinda citrifolia fruits to extract the curcumin and quercetin respectively. Also, their role in oxidative stress was studied using in-vitro techniques.
Results
The percentage (%) yield of hydro-alcoholic extract attained from Curcuma longa rhizomes and Morinda citrifolia fruits were found to be 23.06% and 21.08% respectively.
Conclusion
Additionally, through DPPH (2,2-diphenyl-l-picrylhydrazyl) and Lipid peroxidation (LPO) assay, it was observed that curcumin and quercetin in combination gives the highest antioxidant activity when compared with their individual response at same concentration.
Keywords
Subject
Article metadata
| Title | In vitro Evaluation of Curcumin and Quercetin in Combination on Oxidative Stress |
|---|---|
| Authors | Archita Katrolia; Vedpal; Vikesh Kumar Shukla; Rohit Singh; Sheenu Chandra; Rajeshkumar Raman |
| Affiliations | Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, INDIA; Department of Pharmaceutics, College of Pharmacy, JSS Academy of Technical Education, Noida, Uttar Pradesh, INDIA; Department of Pharmacognosy, College of Pharmacy, JSS Academy of Technical Education, Noida, Uttar Pradesh, INDIA; Centre for Drug Regulatory Affairs and Pharmacy Practice, Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, INDIA; Department of Pharmaceutical Chemistry, College of Pharmacy, JSS Academy of Technical Education, Noida, Uttar Pradesh, INDIA; Department of Pharmaceutical Biotechnology, JSS College of Pharmacy, Ooty, JSS Academy of Higher Education and Research, Myore, INDIA |
| Corresponding author | vkshukla@amity.edu |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 58, Issue 1s (2024) |
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