Use of Liquid Solid Technique for Development and Evaluation Study of Nifedipine Tablets to Enhance Dissolution Characteristics

Objectives

The current research finding suggests dissolution enhancement of nifedipine tablets using Liquid solid technique.

Materials and Methods

The drug's solubility in various liquid carriers has been examined, out of which drug shows maximum solubility in PEG 400 which acts non-volatile liquid solvents. The prepared mixture dissolved with Avicel PH 102 which acts as carrier and Aerosil 200 acts as coating material using formula for Liquid Load Factor (L_f). The blend is then mixed with disintegrating agent Sodium Starch Glycolate (SSG) and other excipients to make the final formulation from which tablets are prepared by direct compression method.

Results

Different physical parameters and in vitro drug release of tablets were evaluated. Comparison of the FTIR spectrum of Nifedipine drugs with the FTIR spectrum physical mixtures in terms of any incompatibility inferred compatibility of that the drug and other excipients with each other. The formulation batch in F1 with 85.81±1.0% dug release occurs within 15 min of time interval indicating better drug release compared with all other batches and it continue up to 120 min showing maximum drug release. The comparison of Drug release pattern of selected Formulation batch F1 with pure drugs and marketed tablets inferred better % cumulative drug release from F1 batch. Liquisolid technique used to enhanced drug release characteristics and consequently improved oral bioavailability.

Conclusion

So, the tablets prepared by this method can be considered as an alternative for improving dissolution of water-insoluble drugs owing to its higher wetting properties and there by greater drug availability for dissolution.