Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 59 | Issue 2 | 2025 | pp. 738–746Open access
Antibacterial Activity of Bacteriocin-Like Inhibitory Substances Produced by Lactic Acid Bacteria Isolated from Cheese against Pathogens
- 1*,
- 1*,
- 1*,
- 1*,
- 1*,
- 1*
- 1 Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, SAUDI ARABIA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Amal Alghamdi
Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, SAUDI ARABIA.
Email: shori_7506@hotmail.com
Copyright: © 2025 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2025
- Received:
- Jul 2, 2024
- Accepted:
- Nov 12, 2024
- DOI:
- 10.5530/ijper.20250239
How to cite
Alghamdi, A., Hesham, K., Alghamdi, S., Kadi, A., Aljohani, A., & Shori, A. (2025). Antibacterial Activity of Bacteriocin-Like Inhibitory Substances Produced by Lactic Acid Bacteria Isolated from Cheese against Pathogens. Indian Journal of Pharmaceutical Education and Research, 59(2), 738–746. https://doi.org/10.5530/ijper.20250239
Abstract
Background
Lactic Acid Bacteria (LAB) produce bacteriocins, which have recently attracted considerable interest as alternatives to antibiotics. Cheese, a fermented food rich in LAB, is highly perishable and susceptible to contamination by foodborne pathogens.
Objectives
This study aims to assess the antibacterial properties of Bacteriocin-Like Inhibitory Substances (BLIS) from four LAB i.e. Lactobacillus fermentum strain NBRC15885 (L. fermentum), Lacticaseibacillus paracasei strain NBRC 15889 (L. paracasei), Pediococcus acidilactici DSM 20284 (P. acidilactici), and Enterococcus faecium strain NBRC 100486 (E. faecium) isolated from Feta cheese sample against several antibiotics and bacterial pathogens.
Materials and Methods
Antibacterial susceptibility test, and Agar well-diffusion test were conducted on LAB isolates.
Results
L. fermentum and E. faecium displayed sensitivity to two types of antibiotics (imipenem and piperacillin). E. faecium BLIS showed the greatest effect on pathogenic bacteria, especially E. coli with an inhibition zone 1.5±0.14 cm.
Conclusion
Bacteriocins produced by the four LAB isolates could effectively inhibit the growth of pathogen bacteria.
Keywords
Subject
Article metadata
| Title | Antibacterial Activity of Bacteriocin-Like Inhibitory Substances Produced by Lactic Acid Bacteria Isolated from Cheese against Pathogens |
|---|---|
| Authors | Amal Alghamdi; Kholoud Hesham; Shahad Alghamdi; Aya Kadi; Aeshah Aljohani; Amal Shori |
| Affiliations | Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, SAUDI ARABIA. |
| Corresponding author | shori_7506@hotmail.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 59, Issue 2 (2025) |
Also in this issue
- Pharmacotherapy of Anorexia Nervosa and Bulimia Nervosa Using SSRIs, MAOIs and TCAspp. 425–432
- Fostering Ethical Decision-Making Skills in Pharmaceutical Education: Vital for Future Pharmacistspp. 433–440
- Pro-Inflammatory Cytokines Predict the Response of Cancer Treatmentpp. 441–452
- Deciphering Molecular Insights into Isocitrate Lyase and their Inhibitors: A Detailed Display through Medicinal Chemistry Windowpp. 453–471
- Insights of Nanoemulsion as a Drug Delivery System: An Overview of Current Trends and Applicationspp. 472–492