Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 59 | Issue 3 | 2025 | pp. 913–922Open access
Formulation and Optimization of Fast Dissolving Thin Strips of Desvenlafaxine HCl by Using Quality by Design (QbD) Approach
- 1,
- 2,
- 3*
- 1 Department of Pharmaceutics, Himalayan School of Pharmaceutical Sciences, Swami Ram Himalayan University, Dehradun, Uttarakhand, INDIA.
- 2 Food and Drug Administration, Price Monitoring Regulatory Unit, FDA, Dehradun, Uttarakhand, INDIA.
- 3 Department of Pharmaceutics, School of Pharmacy, Graphic Era Hill University, Dehradun, Uttarakhand, INDIA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Archana Dhyani
Department of Pharmaceutics, School of Pharmacy, Graphic Era Hill University, Dehradun, Uttarakhand, INDIA.
Email: archana.dhyani@gmail.com
Copyright: © 2025 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2025
- Received:
- Nov 28, 2024
- Accepted:
- Apr 7, 2025
- DOI:
- 10.5530/ijper.20255095
How to cite
Kumar, G., Bhatt, M., & Dhyani, A. (2025). Formulation and Optimization of Fast Dissolving Thin Strips of Desvenlafaxine HCl by Using Quality by Design (QbD) Approach. Indian Journal of Pharmaceutical Education and Research, 59(3), 913–922. https://doi.org/10.5530/ijper.20255095
Abstract
Aim: The present work was aimed to formulate and optimize fast dissolving thin strips of Desvenlafaxine Hydrochloride using QbD. Materials and Methods: The solvent casting method was used to formulate fast dissolving thin strips. The drug (Desvenlafaxine HCl), polymer (pullulan), super disintegrant (Croscarmellose sodium), plasticizer (Poly Ethylene Glycol- (PEG-400), saliva stimulating agent (citric acid), sweetening agent (mannitol and aspartame) and water (solvent) were used in the preparation of the strips. The study involved a 3-level factorial design in which the effect of Pullulan Polymer (A), Croscarmellose Sodium (B) and Poly Ethylene Glycol (C) on 3 response variables disintegration Time (X), percent swelling index (Y) and percent Dissolution Efficiency (DE%15) were analyzed. Results: From the studies, it was found that F12 formulation (containing 30% pullulan, 5% CCS and 7.5% PEG) was the optimized formulation that showed improved important strip characteristics including disintegration time, swelling index and dissolution efficiency after 15 min.
Keywords
Subject
Article metadata
| Title | Formulation and Optimization of Fast Dissolving Thin Strips of Desvenlafaxine HCl by Using Quality by Design (QbD) Approach |
|---|---|
| Authors | Ganesh Kumar; Meenakshi Bhatt; Archana Dhyani |
| Affiliations | Department of Pharmaceutics, Himalayan School of Pharmaceutical Sciences, Swami Ram Himalayan University, Dehradun, Uttarakhand, INDIA.; Food and Drug Administration, Price Monitoring Regulatory Unit, FDA, Dehradun, Uttarakhand, INDIA.; Department of Pharmaceutics, School of Pharmacy, Graphic Era Hill University, Dehradun, Uttarakhand, INDIA. |
| Corresponding author | archana.dhyani@gmail.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 59, Issue 3 (2025) |
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