Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 59 | Issue 3s | 2025 | pp. s1110–s1116Open access
Development of an Ion Chromatography Method for the Determination of Organic Impurities in Ferumoxytol
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- 1*,
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- 1 Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar, Andhra Pradesh, INDIA.
- 2 Department of Physics, Sri Vasavi Engineering College, Pedatadepalli, Tadepalligudem, Andhra Pradesh, INDIA .
- 3 Department of Chemistry, College of Science, King Saud University, Riyadh, SAUDI ARABIA.
- 4 Department of Chemistry, Aditya University, Surampalem, Andhra Pradesh, INDIA .
- 5 Division of Chemistry and Biotechnology, Dongguk University, Dongdaero, Gyeongjusi, Gyeongjusi, SOUTH KOREA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Naga Sankara Rao Deepala
Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar, Andhra Pradesh, INDIA.
Email: rrraju1@gmail.com
Copyright: © 2025 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2025
- Received:
- Nov 16, 2024
- Accepted:
- Apr 2, 2025
- DOI:
- 10.5530/ijper.20251319
How to cite
Deepala, N. S. R., Pedapalli, S., Jagadeesh, K., Islam, M. S., Gadipelli, P., Dahlous, K. A., Alam, M., & Raju, R. R. (2025). Development of an Ion Chromatography Method for the Determination of Organic Impurities in Ferumoxytol. Indian Journal of Pharmaceutical Education and Research, 59(3s), s1110–s1116. https://doi.org/10.5530/ijper.20251319
Abstract
Aim:
To the development of an ion chromatography method for the determination of organic impurities in Ferumoxytol.
Materials and Methods:
A new ion chromatographic method was employed for the precise and suitable quantification of organic impurities in Ferumoxytol drug. Specifically, LOD, LOQ, Linearity, and Accuracy evaluations were conducted to thoroughly validate each of these areas.
Results:
All the studied carbohydrate impurities showed linear ranges within 0.0005 to 0.0030 mg/mL with the correlation coefficients higher than 0.9991. The limits of detection were all less than 0.0002 mg/mL. The limits of quantification were all less than 0.0006 mg/mL. The RSDs of the method were less than 3%.
Conclusion:
This method showed a lot of promise for precise impurity testing in Ferumoxytol drug substance, improving pharmaceutical quality assurance and making sure that patients are protected.
Keywords
Subject
Article metadata
| Title | Development of an Ion Chromatography Method for the Determination of Organic Impurities in Ferumoxytol |
|---|---|
| Authors | Naga Sankara Rao Deepala; Sasikanth Pedapalli; Kantamsetti Jagadeesh; Mohammad Shahidul Islam; Prakash Gadipelli; Kholood A. Dahlous; Mahboob Alam; Rudraraju Ramesh Raju |
| Affiliations | Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar, Andhra Pradesh, INDIA.; Department of Physics, Sri Vasavi Engineering College, Pedatadepalli, Tadepalligudem, Andhra Pradesh, INDIA .; Department of Chemistry, College of Science, King Saud University, Riyadh, SAUDI ARABIA.; Department of Chemistry, Aditya University, Surampalem, Andhra Pradesh, INDIA .; Division of Chemistry and Biotechnology, Dongguk University, Dongdaero, Gyeongjusi, Gyeongjusi, SOUTH KOREA. |
| Corresponding author | rrraju1@gmail.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 59, Issue 3s (2025) |
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