Development and Assessment of a Novel Absorption Base and Permeability-Enhanced Diclofenac Diethylamine Transdermal Cream

Background:

Background of the present research study was to investigate shea butter as absorption base and nerolidol as permeability enhancer for transdermal delivery of diclofenac diethylamine.

Hypothesis:

In present study, the leading objective is to enhance diffusion and permeability of diclofenac diethylamine by using shea butter as absorption base along with nerolidol as permeability enhancer.

Materials and Methods:

Total six batches were prepared (F0-F5) and estimated for physical evaluation, Viscosity, pH, Spreadability, drug content, In vitro drug release and histopathological studies in association with marketed formulation.

Results:

Study showed that prepared transdermal creams were white in color and drug content was around 100% F5 batch was found to be optimized batch among prepared formulation (F0-F5) formulation. In vitro release analysis reveals that the F5 batch had higher drug release than the marketed formulation. The histopathological examination on rat skin permeability sample showed that the F5 formulation demonstrated greater permeation compared to the marketed formulation and the F0 batch.

Conclusion:

F5 batch was found to be optimized batch. The release kinetic data shows that an exponent value of F5 batch was found to be 0.6803, which reveals that release kinetic of F5 batch follows non-fickain drug release mechanism. The histopathological examination of ex vivo permeability rat skin sample confirmed that F5 formulation has greater permeability as compared to F0 and marketed formulation.