Preparation and Pharmacological Evaluation of Potential Hypolipidemic Activity of Yemeni Activated Charcoal

Background: Activated charcoal is a common form of carbon that is used to filter pollutants from water and air, among numerous other uses. It is a very useful adsorbent, due to their high surface area, pore structure, and high degree of surface reactivity. Objectives: To prepare and evaluate the potential hypolipidemic effect of the Yemeni activated charcoal. Materials and Methods: The present study was carried out in vivo by examination of blood lipid components for rabbit before and after therapy and calculating the difference to determine the effect of activated charcoal in comparison to the hypolipidemic standard drug (cholestyramine) and other commercial activated charcoal. In this study the lipid components (cholesterol, triglycerides, HDL, LDL and Risk Factor (RF)) were used as parameters for evaluating the activity of activated charcoal. Results: The prepared activated charcoal was the best product in reducing the lipid components (parameters) that must be reduced by therapy in comparing to standard and similar commercial products, the commercial product was the best in one parameter (HDL) but the worst in three parameters (cholesterol, triglycerides, and LDL). Conclusion: Based on the results obtained from this study, The prepared Yemeni activated charcoal was the best hypolipidemic in comparing to standard drug (Cholestyramine) in all lipid parameters (Cholesterol, triglycerides, HDL, LDL and RF) and also the prepared Yemeni activated charcoal was the best hypolipidemic in comparing to commercial activated charcoal product in four parameters (Cholesterol, triglycerides, LDL and RF).