Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 60 | Issue 2s | pp. s443–s461Open access
Design and Development of Chitosan-Based Posaconazole Loaded Dry Powder by Using BBD
- 1,
- 2*
- 1 Department of Pharmaceutical Technology, Ganpat University, Kherva, Mehsana, Gujarat, INDIA.
- 2 Department of Pharmaceutics, School of Pharmacy and Technology Management (SPTM) SVKM’s NMIMS (Deemed to be University) Mukesh Patel Technology Park, Babulde, Shirpur, Dhule, Maharashtra, INDIA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Shyam Sunder Pancholi
Department of Pharmaceutics, School of Pharmacy and Technology Management (SPTM) SVKM’s NMIMS (Deemed to be University) Mukesh Patel Technology Park, Babulde, Shirpur, Dhule, Maharashtra, INDIA.
Email: sspancholi@gmail.com
- Received:
- Aug 4, 2025
- Accepted:
- Nov 3, 2025
- DOI:
- 10.5530/ijper.20261364
How to cite
Singh, S. K., & Pancholi, S. S. Design and Development of Chitosan-Based Posaconazole Loaded Dry Powder by Using BBD. Indian Journal of Pharmaceutical Education and Research, 60(2s), s443–s461. https://doi.org/10.5530/ijper.20261364
Abstract
Aim: Quality by Design (QbD)-Optimized Spray-Dried Microparticles (prepared by using spray drying process) of Posaconazole-Loaded Chitosan Nanoparticles (POS-CSNPs) for enhanced antifungal efficacy. Materials and Methods: Box-Behnken Design (BBD) a systematic design of experiments was implemented, to screen and optimize the formulation variables for the intended qualities. Results: Outcomes showed that POS-CSNPs have particle size (259.33±6.82 nm), Poly dispersity Index (0.192±0.010), zeta potential (-31.23±0.84 mV) and %Entrapment Efficiency (65.17±1.71). In vitro fungal study result showed the enhanced antifungal and higher fungicidal effect on Rhizopus oryzae strains. Conclusion: From the result it is concluded that the preparation of POS-CSNPs have higher anti-fungal effect on fungus strain.
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Article metadata
| Title | Design and Development of Chitosan-Based Posaconazole Loaded Dry Powder by Using BBD |
|---|---|
| Authors | Sushil Kumar Singh; Shyam Sunder Pancholi |
| Affiliations | Department of Pharmaceutical Technology, Ganpat University, Kherva, Mehsana, Gujarat, INDIA.; Department of Pharmaceutics, School of Pharmacy and Technology Management (SPTM) SVKM’s NMIMS (Deemed to be University) Mukesh Patel Technology Park, Babulde, Shirpur, Dhule, Maharashtra, INDIA. |
| Corresponding author | sspancholi@gmail.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 60, Issue 2s |
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