Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 60 | Issue 3 | 2026 | pp. 1218–1223Open access
Inhibition of miR-224 Repressed Cell Growth, Migration and Invasiveness in Gastric Cancer
- 1*,
- 2,
- 3
- 1 Department of Vascular Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, CHINA.
- 2 Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, CHINA.
- 3 Clinical Research Institute, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, CHINA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Changming Shao
Department of Vascular Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, CHINA.
Email: 2515033@zju.edu.cn
Copyright: © 2026 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2026
- Received:
- Feb 8, 2025
- Accepted:
- Apr 15, 2026
- DOI:
- 10.5530/ijper.20263262
How to cite
Shao, C., Shao, Q., & Shao, Q. (2026). Inhibition of miR-224 Repressed Cell Growth, Migration and Invasiveness in Gastric Cancer. Indian Journal of Pharmaceutical Education and Research, 60(3), 1218–1223. https://doi.org/10.5530/ijper.20263262
Abstract
Aim/Background: MiR-224 has been reported to be associated with many cancers, however, the role of miR-224 in gastric cancer was unclear. Materials and Methods: In the present study, we first used RT-PCR to detect miR-224 level in gastric cancer fresh tissue. Then we performed miR-224 inhibitor transfection in gastric cancer cells, and MTT, cell invasion and migration and colony formation were performed to explore the role of miR-224 in gastric cancer in vitro. Results: The results showed that the relative level of miR-224 in human gastric cancer tissue was significantly higher than that in the adjacent non-tumor gastric mucosa. After transfected by miR-224 inhibitor, the gastric cancer cell proliferation rate was lower compared with the control group, and the migration and invasion are also inhibited by miR-224 inhibitors. The colony number of gastric cancer cells transfected with miR-224 inhibitors was significantly lower than that of the control group. Conclusion: Our results demonstrated that miR-224 is upregulated in gastric cancer. miR-224 inhibitors repressed the proliferation, migration, invasion and colony formation capacity of gastric cancer cells, which indicated that inhibition of miR-224 might be a promising therapeutic option for human gastric cancer.
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Article metadata
| Title | Inhibition of miR-224 Repressed Cell Growth, Migration and Invasiveness in Gastric Cancer |
|---|---|
| Authors | Changming Shao; Qinshu Shao; Qinshu Shao |
| Affiliations | Department of Vascular Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, CHINA.; Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, CHINA.; Clinical Research Institute, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, CHINA. |
| Corresponding author | 2515033@zju.edu.cn |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 60, Issue 3 (2026) |
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