Co-crystals: A Novel Approach to Improve the Solubility of Apixaban

Asati, Amit V; Salunkhe, Kishor S; Singh Rajput, Rudra Pratap; Chintamani, Sonali R; Khairnar, Akshay U; Patil, Nilesh S; Chintamani, Ravindra N

doi:10.5530/ijpi.13.2.033

Original ArticleInternational Journal of Pharmaceutical InvestigationVol. 13 | Issue 2 | pp. 243–247Open access

Co-crystals: A Novel Approach to Improve the Solubility of Apixaban

¹^*,
²,
³,
⁴,
⁵,
⁵,
⁵

¹ Department of Pharmaceutics, Amrutvahini College of Pharmacy, Sangamner, Ahmednagar, Maharashtra, INDIA.
² Department of Pharmaceutics, Sanjivani College of Pharmaceutical Education and Research, Kopargaon, Maharashtra, INDIA.
³ Department of Pharmaceutics, Columbia Institute of Pharmacy, Raipur, Chhattisgarh, INDIA.
⁴ Department of Pharmaceutics, MCE Society’s Allana College of Pharmacy, Pune, Maharashtra, INDIA.
⁵ Department of Pharmaceutics, Rajmata Jijau Shikshan Prasarak Mandal’s, Institute of Pharmacy, Pune, Maharashtra, INDIA.

Correspondence: Amit V Asati
Department of Pharmaceutics, Amrutvahini College of Pharmacy, Sangamner, Ahmednagar, Maharashtra, INDIA.
Email: avasati28@rediffmail.com

Received:: Nov 16, 2022
Accepted:: Jan 4, 2023
DOI:: 10.5530/ijpi.13.2.033

How to cite

Asati, A. V., Salunkhe, K. S., Rajput, R. P. S., Chintamani, S. R., Khairnar, A. U., Patil, N. S., & Chintamani, R. N. Co-crystals: A Novel Approach to Improve the Solubility of Apixaban. International Journal of Pharmaceutical Investigation, 13(2), 243–247. https://doi.org/10.5530/ijpi.13.2.033

Abstract

Objectives: The current study work was aimed to improve the solubility of Apixaban by forming co-crystals. Materials and Methods: Two solvents mainly Dimethyl Sulphoxide (DMSO) and 2,2,2-trifluoroethanol were tried during the formulation of co-crystals. The other chemicals oxalic acid, adipic acid and L-Tartaric acid were used. Results: From the different trials it was concluded that oxalic acid and DMSO combination with the drug gave the better results for improvement in the solubility. Hence the batch F3 was analysed further. The melting point of F3 was found lower than pure drug. Drug content was found optimum as 95.06 ±0.65%. FTIR-spectra demonstrated the combined peaks of drug and oxalic acid. DSC thermogram showed the sharp endothermic peak similar to pure drug. SEM and XRD spectra confirmed the formation of co-crystals. Conclusion: It was found that formation of co-crystals of apixaban and oxalic acid was satisfactory and it was beneficial to improve the solubility of the apixaban

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Article metadata

Title	Co-crystals: A Novel Approach to Improve the Solubility of Apixaban
Authors	Amit V Asati; Kishor S Salunkhe; Rudra Pratap Singh Rajput; Sonali R Chintamani; Akshay U Khairnar; Nilesh S Patil; Ravindra N Chintamani
Affiliations	Department of Pharmaceutics, Amrutvahini College of Pharmacy, Sangamner, Ahmednagar, Maharashtra, INDIA.; Department of Pharmaceutics, Sanjivani College of Pharmaceutical Education and Research, Kopargaon, Maharashtra, INDIA.; Department of Pharmaceutics, Columbia Institute of Pharmacy, Raipur, Chhattisgarh, INDIA.; Department of Pharmaceutics, MCE Society’s Allana College of Pharmacy, Pune, Maharashtra, INDIA.; Department of Pharmaceutics, Rajmata Jijau Shikshan Prasarak Mandal’s, Institute of Pharmacy, Pune, Maharashtra, INDIA.
Corresponding author	avasati28@rediffmail.com
Journal	International Journal of Pharmaceutical Investigation
Volume / Issue	Vol. 13, Issue 2

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