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Original ArticleInternational Journal of Pharmaceutical InvestigationVol. 14 | Issue 2 | 2024 | pp. 539–546Open access
In vitro and In vivo Immunomodulatory Activity of Hydro Ethanolic Extract of Grewia hirsuta Vahl.
- 1*,
- 2,
- 3,
- 4
- 1 Department of Pharmacology, SCS College of Pharmacy, Harapanahalli, Karnataka, INDIA.
- 2 Department of Pharmacology, SET’s College of Pharmacy, S R Nagar, Dharwad, Karnataka, INDIA.
- 3 Department of Pharmacognosy, SET’s College of Pharmacy, S R Nagar, Dharwad, Karnataka, INDIA.
- 4 Department of Pharmacy, Himgiri Zee University, Dehradun, Uttarakhand, INDIA.
Published in International Journal of Pharmaceutical Investigation
Correspondence: Vinuth Chikkamath
Department of Pharmacology, SCS College of Pharmacy, Harapanahalli, Karnataka, INDIA.
Email: vinuth6288@gmail.com
Copyright: © 2024 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2024
- Received:
- Jan 22, 2024
- Accepted:
- Feb 28, 2024
- DOI:
- 10.5530/ijpi.14.2.65
How to cite
Chikkamath, V., Kulkarni, V., Habbu, P., & Nagappa, A. N. (2024). In vitro and In vivo Immunomodulatory Activity of Hydro Ethanolic Extract of Grewia hirsuta Vahl. International Journal of Pharmaceutical Investigation, 14(2), 539–546. https://doi.org/10.5530/ijpi.14.2.65
Abstract
Background
The Advent of the COVID -19 pandemic has necessitated the quick exploration of new drugs. Synthetic approach is time consuming and expensive with uncertainty. The natural products can be explored as this approach is cost effective and takes less time to investigate. The ethnic significance of Grewia hirsuta has given clues of Immunomodulator potential. Hydro ethanolic extract of Grewia hirsuta was explored and compared with established levamisole.
Materials and Methods
In vitro, immunomodulator models on human lymphocytes and In vivo carbon clearance model in Swiss albino mice were studied by lymphotoxicity and lymphocyte proliferation.
Results
Hydro ethanolic extract of Grewia hirsuta has shown similar results of immunomodulation comparable with levamisole in statistically significant studies assessed by Dunnett’s test.
Conclusion
Hydro ethanolic extract has shown decreased lymphocyte toxicity and increased lymphocyte proliferation.
Keywords
Subject
Article metadata
| Title | In vitro and In vivo Immunomodulatory Activity of Hydro Ethanolic Extract of Grewia hirsuta Vahl. |
|---|---|
| Authors | Vinuth Chikkamath; Venkatrao Kulkarni; Prasanna Habbu; Anantha Naik Nagappa |
| Affiliations | Department of Pharmacology, SCS College of Pharmacy, Harapanahalli, Karnataka, INDIA.; Department of Pharmacology, SET’s College of Pharmacy, S R Nagar, Dharwad, Karnataka, INDIA.; Department of Pharmacognosy, SET’s College of Pharmacy, S R Nagar, Dharwad, Karnataka, INDIA.; Department of Pharmacy, Himgiri Zee University, Dehradun, Uttarakhand, INDIA. |
| Corresponding author | vinuth6288@gmail.com |
| Journal | International Journal of Pharmaceutical Investigation |
| Volume / Issue | Vol. 14, Issue 2 (2024) |
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