Mesalamine-Loaded Microsponges as a Potential Strategy for Colon-Specific Anti-Inflammatory Therapy: Design and Evaluation

Background

This study aimed to develop an efficient drug delivery system targeting the colon to treat inflammatory conditions using mesalamine. The approach involved formulating microsponges with Eudragit polymers, focusing on assessing the in vitro drug release patterns.

Materials and Methods

The quasi-emulsion solvent diffusion method was employed using various Eudragit polymers (S100, L100, RS100 and RL100). Critical parameters, such as entrapment efficiency, particle size and drug release, were systematically examined. Different kinetic models have been used to understand the mechanism of drug release.

Results and Discussion

The developed microsponges met the desired entrapment efficiency and particle size standards. Drug release from these formulations exhibited a diffusion-based pattern aligned with a zero-order kinetic model. Initial 1-2 hr showed minimal drug release (2-1%), whereas a significant release (92-95%) occurred within 24 hr for formulations F1 and F2. This release behaviour suggests the potential of sustained and pH-dependent drug delivery applications.

Conclusion

This study contributes to the field by successfully designing a colon-targeted drug delivery system for mesalamines. Using Eudragit polymers and incorporating microsponges showed the potential for sustained drug release, emphasizing their applicability for treating inflammatory colon conditions. This study provides a foundation for future drug-delivery systems targeting specific gastrointestinal regions.