Advances in Collagen Biomaterials for Dental Applications: A Review from Biofabrication to Clinical Practice

This review article provides a comprehensive examination of collagen-loaded dental applications, focusing on collagen dental plugs used for socket preservation and tissue regeneration following tooth extraction. It explores the biofabrication and development of these biomaterials, emphasizing advanced manufacturing techniques, material characterization, and innovative technologies such as electrospinning and 3D printing. The review evaluates the clinical efficacy of collagen dental plugs through systematic analysis of clinical trials and case studies, highlighting their effectiveness, patient outcomes, and challenges. Regulatory and quality control aspects are discussed, including compliance with international standards and ensuring safety and biocompatibility. Future directions in collagen-based biomaterials are explored, including advancements in personalized and precision dental care, integration of nano- and micro-technologies, and the development of eco-friendly and sustainable products. The article underscores the significant impact of these advancements on patient care and the potential for ongoing innovation in dental biomaterials.