Review ArticleInternational Journal of Pharmaceutical InvestigationVol. 16 | Issue 1 | 2026 | pp. 105–110Open access
Exploring Cubosomes as an Emerging Approach of Novel Drug Delivery System: A Review
- 1,
- 1*,
- 2,
- 3,
- 4,
- 5,
- 6
- 1 Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences (NGSMIPS), NITTE (Deeemed to be University), Mangalore, INDIA.
- 2 Department of Pharmaceutical Formulation, Granules Pharmaceuticals Inc, Virginia, UNITED STATES OF AMERICA.
- 3 Department of Pharmaceutics, JSS College of Pharmacy, Mysuru, JSS Academy of Higher Education and Research, Mysuru, Karnataka, INDIA.
- 4 Department of Pharmaceutical Analysis, KMCT Institute of Pharmaceutical Education and Research, Kozhikode, Kerala, INDIA.
- 5 Department of Pharmaceutics, GM Institute of Pharmaceutical Sciences and Research, Davangere, Karnataka, INDIA.
- 6 Department of Pharmaceutical Analysis, MB School of Pharmaceutical Sciences, Mohan Babu University, Sree Sainath Nagar, Tirupati, Andrapradesh, INDIA.
Published in International Journal of Pharmaceutical Investigation
Correspondence: DS Sandeep
Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences (NGSMIPS), NITTE (Deeemed to be University), Mangalore, INDIA.
Email: sandypharama@gmail.com
Copyright: © 2026 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2026
- Received:
- May 2, 2025
- Accepted:
- Aug 18, 2025
- DOI:
- 10.5530/ijpi.20260359
How to cite
Amitha, N., Sandeep, D., Rajanikant, P., Gowrav, M., Kathirvel, S., Pradeep, H., & Jeyaprakash, M. (2026). Exploring Cubosomes as an Emerging Approach of Novel Drug Delivery System: A Review. International Journal of Pharmaceutical Investigation, 16(1), 105–110. https://doi.org/10.5530/ijpi.20260359
Abstract
Cubosomes are self-assembled nanostructures that exhibit a bicontinuous cubic phase. These nanoparticles can incorporate many drugs, including amphiphilic, hydrophilic, and lipophilic substances. The structure of cubosomes is typically analyzed using techniques such as NMR, electron microscopy, X-ray diffraction, and light scattering. Cubosomes, fabricated from biocompatible and biodegradable lipids such as phytantriol and monoolein, are considered safe drug delivery carriers. They are particularly effective in enhancing the solubility of poorly water-soluble drugs and offer site-specific drug delivery, a low dissociation rate, and improved drug retention. Common methods for preparing cubosomes include spray drying, ultrasonication, solvent evaporation, and hydrotrope. Cubosomes are widely used for ocular, transdermal, and oral drug delivery approaches as well as in cancer therapy.
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Article metadata
| Title | Exploring Cubosomes as an Emerging Approach of Novel Drug Delivery System: A Review |
|---|---|
| Authors | N Amitha; DS Sandeep; P Rajanikant; MP Gowrav; S Kathirvel; HK Pradeep; MR Jeyaprakash |
| Affiliations | Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences (NGSMIPS), NITTE (Deeemed to be University), Mangalore, INDIA.; Department of Pharmaceutical Formulation, Granules Pharmaceuticals Inc, Virginia, UNITED STATES OF AMERICA.; Department of Pharmaceutics, JSS College of Pharmacy, Mysuru, JSS Academy of Higher Education and Research, Mysuru, Karnataka, INDIA.; Department of Pharmaceutical Analysis, KMCT Institute of Pharmaceutical Education and Research, Kozhikode, Kerala, INDIA.; Department of Pharmaceutics, GM Institute of Pharmaceutical Sciences and Research, Davangere, Karnataka, INDIA.; Department of Pharmaceutical Analysis, MB School of Pharmaceutical Sciences, Mohan Babu University, Sree Sainath Nagar, Tirupati, Andrapradesh, INDIA. |
| Corresponding author | sandypharama@gmail.com |
| Journal | International Journal of Pharmaceutical Investigation |
| Volume / Issue | Vol. 16, Issue 1 (2026) |
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