A Review on Impact of Syzygium aromaticum, Nigella sativa, and Mesua ferrea on Alzheimer’s Disease

Alzheimer's Disease (AD), characterised by cognitive impairment and memory loss, is primarily caused by the deterioration of the central nervous system, which is a vital component of the human body. Amyloid-beta plaque buildup in the brain and cognitive impairment are two hallmarks of AD, a progressive neurodegenerative disease. AD involves neuroinflammation that contributes to its progression, signifying the important need for neuroprotection to reduce brain damage and improve patient outcomes. sEH has gained attention as a potential therapeutic target due to its role in modulating neuroinflammation and promoting neuroprotection. There are significant therapeutic gaps as a result of numerous researchers’ inability to develop medications with neuroprotective properties that target AD, highlighting the continuing challenges in the effective treatment of this severe illness. Inhibition of sEH activity by medicinal plants such as Mesua ferrea (Ceylon ironwood), Nigella sativa (black seed), and Syzygium aromaticum (clove) could have neuroprotective effects. These plants neuroprotective effects, their role as sEH inhibitors. As well as the impact of sEH in the development of AD is emphasized in this review.