Design and development and evaluation of candesartan cilexetil liquid filling formulations

Most of the currently available drugs are having poor water solubility and suffer from low oral bioavailability. One of the most promising approaches to deliver such insoluble drugs is by dissolving it in lipids, liquids or semi-solids to formulate new products.[1] Candesartan meets the requirement of high potency but it is poorly absorbed when administered as tablets. Therefore the prodrug Candesartan cilexitil is developed.[2] Two piece hard gelatin liquid filling capsules are one of the most logical approaches when choosing the best dosage form to deliver these new liquid formulations.[1] Liquid filled formulations were prepared by employing different cosolvents and surfactants. The formulation containing SLS-2%, PVP- 17.5%, PEG-15%, and PG-53% exhibited desire solubility, rheological property and found to be stable in hard gelatin capsules.