Review ArticleJournal of Pharmacy Practice and Community MedicineVol. 5 | Issue 1 | pp. 03–12Open access
The Virulence of Helicobacter pylori Through CagA on Gastric Mucosa: A Review
- 1,
- 2,
- 2,
- 3,
- 3,
- 4,5,6,8*,
- 7,
- 8,
- 9,10
- 1 Registrar, Department of Nephrology Northwest General Hospital Hayatabad Peshawar, Pakistan, PAKISTAN.
- 2 Departmet of Gastroenterology Second affiliated hospital, Xi'an Jiaotong University, School of medicine, Shaanxi 710061, Xi'an, CHINA.
- 3 Department of Clinical Endocrinology Xi’an Jiaotong University, First Affiliated Hospital, Xi’an, Shanxi, CHINA.
- 4 Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Health Science Centre, Xi’an Jiaotong University, CHINA.
- 5 Center for Drug Safety and Policy Research, Xi’an Jiaotong University, Xi’an, CHINA.
- 6 The Global Health Institute, Xi’an Jiaotong University, Xi’an, China; d Shaanxi Centre for Health Reform and Development Research, Xi’an, CHINA.
- 7 Department of Pharmacology, Institute of Health Sciences, Cukurova University, Adana, TURKEY.
- 8 Department of Pharmacy Quaid-i-Azam University Islamabad, PAKISTAN.
- 9 School of Pharmacy, Monash University Malaysia Jalan Lagoon Selantan Bandar Sunway, MALAYSIA.
- 10 Department of Pharmacy, Abdul Wali Khan University, Mardan, PAKISTAN.
Published in Journal of Pharmacy Practice and Community Medicine
Correspondence: Faiz Ullah Khan
Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Health Science Centre, Xi’an Jiaotong University, CHINA.; Center for Drug Safety and Policy Research, Xi’an Jiaotong University, Xi’an, CHINA.; The Global Health Institute, Xi’an Jiaotong University, Xi’an, China; d Shaanxi Centre for Health Reform and Development Research, Xi’an, CHINA.; Department of Pharmacy Quaid-i-Azam University Islamabad, PAKISTAN.
Email: fkhan@bs.qau.edu.pk
- Received:
- Dec 27, 2018
- Accepted:
- Feb 17, 2019
- DOI:
- 10.5530/jppcm.2019.1.2
How to cite
Hussain, S., Li, Z., Lu, X., Khan, H. H., bingyin, S., Khan, F. U., Khan, Z., Ashfaq, B., & Rehman, I. U. The Virulence of Helicobacter pylori Through CagA on Gastric Mucosa: A Review. Journal of Pharmacy Practice and Community Medicine, 5(1), 03–12. https://doi.org/10.5530/jppcm.2019.1.2
Abstract
Helicobacter pylori (H. pylori), is the most common infectious bacterium of the Human stomach. In early childhood, colonization of H. pylori in stomach releases different pathogenic factors which interfere with functions of human cells. Combination of two main genetic pathogenic factors CagA and VacA play important role in causing severity of H. pylori infection. In H. pylori infected patients, CagA and CagPAI positive strains have positive association in development of peptic ulcer disease and gastric cancers.50-70% of H. pylori produces CagA gene that is multifunction toxin. By adapting different mechanisms CagA define its role in oncogenic signaling cascades, in tumor suppressor pathway and in inflammation. CagA gene is strongly associated with VacA cytotoxic function and the strains, ultimately responsible for epithelial destruction of stomach and leading towards cancer. Review provides, CagA has important role in the virulence of H.pylori infection. Different Peptic ulcer diseases and gastric cancers are caused by the presence of CagA gene.
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Article metadata
| Title | The Virulence of Helicobacter pylori Through CagA on Gastric Mucosa: A Review |
|---|---|
| Authors | Shida Hussain; Zhang Li; Xiaolan Lu; Hamad Haider Khan; Shi bingyin; Faiz Ullah Khan; Zakir Khan; Beenish Ashfaq; Inayat Ur Rehman |
| Affiliations | Registrar, Department of Nephrology Northwest General Hospital Hayatabad Peshawar, Pakistan, PAKISTAN.; Departmet of Gastroenterology Second affiliated hospital, Xi'an Jiaotong University, School of medicine, Shaanxi 710061, Xi'an, CHINA.; Department of Clinical Endocrinology Xi’an Jiaotong University, First Affiliated Hospital, Xi’an, Shanxi, CHINA.; Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Health Science Centre, Xi’an Jiaotong University, CHINA.; Center for Drug Safety and Policy Research, Xi’an Jiaotong University, Xi’an, CHINA.; The Global Health Institute, Xi’an Jiaotong University, Xi’an, China; d Shaanxi Centre for Health Reform and Development Research, Xi’an, CHINA.; Department of Pharmacology, Institute of Health Sciences, Cukurova University, Adana, TURKEY.; Department of Pharmacy Quaid-i-Azam University Islamabad, PAKISTAN.; School of Pharmacy, Monash University Malaysia Jalan Lagoon Selantan Bandar Sunway, MALAYSIA.; Department of Pharmacy, Abdul Wali Khan University, Mardan, PAKISTAN. |
| Corresponding author | fkhan@bs.qau.edu.pk |
| Journal | Journal of Pharmacy Practice and Community Medicine |
| Volume / Issue | Vol. 5, Issue 1 |
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