Evaluation of Silver Nanoparticles Addition in Periodontal Dressing for Wound Tissue Healing by 99mTc-ciprofloxacin

Objective: Periodontal dressing is a protective material that is used on post-surgical periodontal to protect the surface of the wound and provides a comfort sense to patient. This study was conducted to determine the effect of periodontal dressings containing silver nanoparticles by evaluating inflammatory parameters using 99mTc-ciprofloxacin; a radiopharmaceutical that can be used for diagnosing infection and inflammation. Methods: This research was carried out using purely experimental 24 male Sprague Dawley rats and divided into 4 groups. First group is a group without any treatment, second group was the positive control group (excision procedure and given CoePak(R)), third group was negative group (only excision procedure) and fourth group (excision procedure and given CoePak (R) with silver nanoparticles). On second and fourth days after the procedure, each group was observed of inflammation inside of the excision by injecting 99mTc-ciprofloxacin through vein and after one hour the rat was sacrificed and dextra palate organ of each rat was counted by Single Channel Analyzer to determine the accumulation of 99mTc-ciprofloxacin. Results: In rats given CoePak (R) with silver nanoparticles showed a tendency or inclination data which is good in giving effect to promote healing compare to positive control group on day 4 with less accumulation of 99mTc-ciprofloxacin in dextra palate. Conclusion: Addition of silver nanoparticles in periodontal dressing gave a good effect for wound tissue healing.