Neuroprotective Activity of Methanolic extract of Terminala bellerica Fruit against Aluminium Chloride and Haloperidol Induced Amnesia in Mice

Objectives: The data presented in the article is related to evaluation of Terminalia bellerica fruits methanol extract (METB) for the neurodegenerative disorders along with their antioxidant potential. Methods: Various phytoconstituents were identified with proximate phytochemical analysis of METB. Terminalia species are gallic acid and chebulaginic acid which are known to possess neuroprotective activity and are also known to contain various flavonoids and phenols as active constituents. The methanolic fruit extract of Terminalia bellerica was screened for its Neuroprotective Activity against Aluminium Chloride and Haloperidol Induced Amnesia in Mice. Results: In vitro AChEs assay, METB showed IC50 34.5µg/ml and also significantly reduced brain AChE. In addition, it exhibited remarkable radical scavenging potential in reducing power assay (increasing absorbance) and lipid peroxidation assays (IC50 39.25 µg/ml). In vivo neuroprotective activities were performed via the passive avoidance, plus maze tasks in aluminium chloride induced amnesia model and via rota rod apparatus, standard bar test in haloperidol induced catalepsy model. METB showed significant (p< 0.01, p< 0.05) improvement in cognitive impairment in aluminium chloride induced amnesia animal models and moderate inhibitory activities. The results demonstrate that the anti-amnesic effect of METB may be mediated via antioxidant capabilities, as well as inhibition of AChEs and due to the presence of various terpenoids, flavonoids and phenols as active constituents. Conclusion: Furthermore Terminalia bellerica ayurvedic plant can be used in various neurological disorders.