Synthesis and Biological Evaluation of some 3b-hydroxy-lup-20(29)-en-28-oic Acid Derivatives

Sharma, Prince Prashant; A, Anurag; Roy, Ram Kumar; Kaushik, Rajneesh Dutt; Sharma, Vipin Kumar

doi:10.5530/jyp.2016.4.5

Original ArtcileJournal of Young PharmacistsVol. 8 | Issue 4 | pp. 319–323Open access

Synthesis and Biological Evaluation of some 3b-hydroxy-lup-20(29)-en-28-oic Acid Derivatives

¹^*,
²,
³,
⁴,
⁵

¹ Department of Pharmaceutical Sciences, Faculty of Medical Sciences and Health, Gurukula Kangri University, Haridwar-249404, Uttarakhand, INDIA.
² Meerut Institute of Engineering and Technology (MIET), NH-58 Meerut-Delhi Bypass, Meerut, Uttar Pradesh, INDIA.
³ Innovative College of Pharmacy, Knowledge Park-ii, Greater Noida, Uttar Pradesh, INDIA.
⁴ Department of Chemistry, Faculty of Sciences, Gurukula Kangri University, Haridwar-249404, Uttarakhand, INDIA.
⁵ Department of Pharmaceutical Sciences, Faculty of Medical Sciences and Health, Gurukula Kangri University, Haridwar-249404, Uttarakhand, INDIA.

Correspondence: Prince Prashant Sharma
Department of Pharmaceutical Sciences, Faculty of Medical Sciences and Health, Gurukula Kangri University, Haridwar-249404, Uttarakhand, INDIA.
Email: princeb4me@rediffmail.com

DOI:: 10.5530/jyp.2016.4.5

How to cite

Sharma, P. P., A, A., Roy, R. K., Kaushik, R. D., & Sharma, V. K. Synthesis and Biological Evaluation of some 3b-hydroxy-lup-20(29)-en-28-oic Acid Derivatives. Journal of Young Pharmacists, 8(4), 319–323. https://doi.org/10.5530/jyp.2016.4.5

Abstract

Objective: The present study projected to the synthesis of 3b-Hydroxy-lup- 20(29)-en-28-oic acid analogues in order to evaluate their possible biological activity. In addition, the structure–activity relationship is also investigated. Method: BA derivatives were prepared by conjugating 3b-Hydroxy-lup- 20(29)-en-28-oic acid with different amines through carbomyl linkage. Structures of synthesized compounds were elucidated by spectral data. Cytotoxic evaluation was done by CAM assay and MTT assay. Results: Among the synthesized compounds, Compound 7showed a pronounced cytotoxicity in antiangiogenic assay as well as compound ECV-304 cell line. Compound 10 also showed good cytotoxic activity. While compounds 6 and 8 showed moderate activity against A-549 and MCF-7 respectively. Conclusion: It is concluded that synthesized BA analogues are biologically active and developed into useful anticancer agents.

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Article metadata

Title	Synthesis and Biological Evaluation of some 3b-hydroxy-lup-20(29)-en-28-oic Acid Derivatives
Authors	Prince Prashant Sharma; Anurag A; Ram Kumar Roy; Rajneesh Dutt Kaushik; Vipin Kumar Sharma
Affiliations	Department of Pharmaceutical Sciences, Faculty of Medical Sciences and Health, Gurukula Kangri University, Haridwar-249404, Uttarakhand, INDIA.; Meerut Institute of Engineering and Technology (MIET), NH-58 Meerut-Delhi Bypass, Meerut, Uttar Pradesh, INDIA.; Innovative College of Pharmacy, Knowledge Park-ii, Greater Noida, Uttar Pradesh, INDIA.; Department of Chemistry, Faculty of Sciences, Gurukula Kangri University, Haridwar-249404, Uttarakhand, INDIA.; Department of Pharmaceutical Sciences, Faculty of Medical Sciences and Health, Gurukula Kangri University, Haridwar-249404, Uttarakhand, INDIA.
Corresponding author	princeb4me@rediffmail.com
Journal	Journal of Young Pharmacists
Volume / Issue	Vol. 8, Issue 4

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