Antioxidant Potential of Ethanolic Extract of Canavalia Species in High‑fat Diet and Streptozotocin‑induced Diabetic Rats

Background: The present study is to enlighten the antioxidant effect of ethanolic seed extracts of Canavalia species in high‑fat diet and streptozotocin (HFD + STZ)‑induced diabetic screening model. Objectives: The dispute between free radicals and antioxidants plays a key role in causing alteration of normal physiological conditions. Inadequate antioxidant in body leads to multiple pathological diseases. Materials and Methods: Ethanolic seed extracts of Canavalia species have been investigated for its antioxidant activity in HFD + STZ‑induced screening models. The potential of antioxidants on oxidative stress is measured through certain serum biomarkers such as serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, and alkaline phosphatase. Enzymatic markers include lipid peroxidation, catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH). Enzymatic parameters were studied in liver and kidney homogenates by measuring these observed biomarkers. Results: SOD, GSH, and CAT were decreased in the diabetic group. However, restoration of SOD, GSH, and CAT levels by treatment with ethanolic seed extracts of Canavalia species was observed and tabulated. Histopathological studies of the pancreas of animals showed comparable regeneration of tissues with EECE. Conclusion: Further the characterization studies will be carried out to know the extract mechanism of antioxidant potential of Canavalia species.