Physicochemical, Toxicity and Antioxidant Activity of Terminalia catappa Kernel Oil in Mice

Halilu, Emmanuel Mshelia; Ugwah-Oguejiofor, Chinenye Jane; Oduncuoğlu, Göksu; Matthias, Solomon Gamde

doi:10.5530/097484900304

Original ArticlePharmacognosy ResearchVol. 15 | Issue 1 | pp. 119–127Open access

Physicochemical, Toxicity and Antioxidant Activity of Terminalia catappa Kernel Oil in Mice

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³

¹ Department of Pharmacognosy, Faculty of Pharmacy, Cyprus International University, Nicosia, North Cyprus, Mersin 10, TURKEY.
² Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, NIGERIA.
³ Department of Histopathology, Faculty of Health Sciences and Technology, University of Jos, Plateau, NIGERIA.
⁴ Department of Pharmacognosy and Ethnopharmacy, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, NIGERIA.

Correspondence: Emmanuel Mshelia Halilu
Department of Pharmacognosy, Faculty of Pharmacy, Cyprus International University, Nicosia, North Cyprus, Mersin 10, TURKEY.; Department of Pharmacognosy and Ethnopharmacy, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, NIGERIA.
Email: emshelia2002@gmail.com

Received:: Oct 22, 2022
Accepted:: Nov 19, 2022
DOI:: 10.5530/097484900304

How to cite

Halilu, E. M., Ugwah-Oguejiofor, C. J., Oduncuoğlu, G., & Matthias, S. G. Physicochemical, Toxicity and Antioxidant Activity of Terminalia catappa Kernel Oil in Mice. Pharmacognosy Research, 15(1), 119–127. https://doi.org/10.5530/097484900304

Abstract

Background: Terminalia catappa Linn. is an ornamental tree belonging to the family Combretaceae. This study was aimed at evaluating the toxicity profile and antioxidant activity of the oil. Materials and Methods: Oral acute and sub-acute toxicity were studied in mice using the Organization for Economic Co-operation and Development (OECD) guidelines. The antioxidant activity was assessed using DPPH free radical. Results: Terminalia catappa seed oil demonstrated antioxidant activity by scavenging DPPH free radical with IC50 of 1.425 mg/mL while tannic acid (standard) was 5.005 mg/mL. The oral LD50 of the oil in mice was greater than 5000 mg/kg. The sub-acute toxicity study, produced no significant difference in the weight and biochemical parameters in treated animals compared to the control. Conclusion: The oil was also non-toxic to the liver, kidney, heart and lungs on histopathological examination. Our results indicated that Terminalia catappa seed oil is not toxic and contains beneficial phytochemical that demonstrated antioxidant activity.

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Article metadata

Title	Physicochemical, Toxicity and Antioxidant Activity of Terminalia catappa Kernel Oil in Mice
Authors	Emmanuel Mshelia Halilu; Chinenye Jane Ugwah-Oguejiofor; Göksu Oduncuoğlu; Solomon Gamde Matthias
Affiliations	Department of Pharmacognosy, Faculty of Pharmacy, Cyprus International University, Nicosia, North Cyprus, Mersin 10, TURKEY.; Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, NIGERIA.; Department of Histopathology, Faculty of Health Sciences and Technology, University of Jos, Plateau, NIGERIA.; Department of Pharmacognosy and Ethnopharmacy, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, NIGERIA.
Corresponding author	emshelia2002@gmail.com
Journal	Pharmacognosy Research
Volume / Issue	Vol. 15, Issue 1

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