Review ArticlePharmacognosy ReviewsVol. 14 | Issue 27 | pp. 62–71Open access
Neuroprotective Effects of Guanosine Supplementation in Experimental Models: A Systematic Review
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- 1 Laboratory of Experimental Neurology, Department of Biomedical Sciences, Health Sciences Center, State University of Rio Grande do Norte (UERN), Mossoró-RN,, BRAZIL.
- 2 Postgraduate Program in Biotechnology at Potiguar University (UnP) - Laureate International Universities – Natal, BRAZIL.
Published in Pharmacognosy Reviews
Correspondence: Fausto Pierdoná Guzen
Laboratory of Experimental Neurology, Department of Biomedical Sciences, Health Sciences Center, State University of Rio Grande do Norte (UERN), Mossoró-RN,, BRAZIL.; Postgraduate Program in Biotechnology at Potiguar University (UnP) - Laureate International Universities – Natal, BRAZIL.
Email: faustoguzen@uern.br
- Received:
- Mar 2, 2020
- Accepted:
- May 28, 2020
- DOI:
- 10.5530/phrev.2020.14.10
How to cite
Bezerra, A. P. D. C., Pedrosa, E. C. G. A., Costa, I. M. D., Cavalcanti, J. R. L. D. P., Cavalcanti, J. R. L. D. P., Oliveira, L. C. D., Araújo, D. P. D., Rego, A. C. M. D., Araújo-Filho, I., Pinheiro, F. I., & Guzen, F. P. Neuroprotective Effects of Guanosine Supplementation in Experimental Models: A Systematic Review. Pharmacognosy Reviews, 14(27), 62–71. https://doi.org/10.5530/phrev.2020.14.10
Abstract
Guanosine (GUO) is an endogenous guanine nucleoside to which several neuroprotective and neurotrophic effects have been attributed in experimental in vitro and/or in vivo models of central nervous system (CNS) diseases, including ischemic stroke, Alzheimer’s, Parkinson’s disease, spinal cord injury, nociception and depression. The objective of this work is to systematically review the neuroprotective effects of guanosine in experimental models in the CNS. The research was conducted through PubMed, Science direct, Scopus, Cochrane Library and SciELO (Scientific Electronic Library Online) and databases, where a number of relevant articles were found. Central nervous system (CNS) astrocytes release guanosine extracellularly, that has trophic effects. In the CNS, extracellular guanosine (GUO) stimulates mitosis, the synthesis of trophic factors and cell differentiation, including neuritogenesis, is neuroprotective and reduces apoptosis due to various stimuli. In this work we demonstrate that guanosine has a neuroprotective effect, through the survey of data that we carry out.
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Article metadata
| Title | Neuroprotective Effects of Guanosine Supplementation in Experimental Models: A Systematic Review |
|---|---|
| Authors | Ana Paula De Carvalho Bezerra; Elayne Cristina Gurgel Andrade Pedrosa; Ianara Mendonça Da Costa; Jose Rodolfo Lopes De Paiva Cavalcanti; Jose Rodolfo Lopes De Paiva Cavalcanti; Lucidio Clebeson De Oliveira; Dayane Pessoa De Araújo; Amália Cinthia Menezes Do Rego; Irami Araújo-Filho; Francisco Irochima Pinheiro; Fausto Pierdoná Guzen |
| Affiliations | Laboratory of Experimental Neurology, Department of Biomedical Sciences, Health Sciences Center, State University of Rio Grande do Norte (UERN), Mossoró-RN,, BRAZIL.; Postgraduate Program in Biotechnology at Potiguar University (UnP) - Laureate International Universities – Natal, BRAZIL. |
| Corresponding author | faustoguzen@uern.br |
| Journal | Pharmacognosy Reviews |
| Volume / Issue | Vol. 14, Issue 27 |
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