Review ArticlePharmacognosy ReviewsVol. 7 | Issue 14 | pp. 121–130Open access
Cholinesterase inhibitors from botanicals
- 1*,
- 2,
- 1,
- 3
- 1 Indian Institute of Crop Processing Technology, Ministry of Food Processing Industries, Government of India, Thanjavur, INDIA.
- 2 Department of Chemistry, Kulliyyah of Science, IIUM, Kuantan, MALAYSIA.
- 3 Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, KINGDOM OF SAUDI ARABIA.
Published in Pharmacognosy Reviews
Correspondence: Faiyaz Ahmed
Indian Institute of Crop Processing Technology, Ministry of Food Processing Industries, Government of India, Thanjavur, INDIA.
Email: faiyazahmed@iicpt.edu.in
- Received:
- Feb 26, 2013
- DOI:
- 10.4103/0973-7847.120511
How to cite
Ahmed, F., Ghalib, R. M., Sasikala, P., & Ahmed, K. K. M. Cholinesterase inhibitors from botanicals. Pharmacognosy Reviews, 7(14), 121–130. https://doi.org/10.4103/0973-7847.120511
Abstract
Alzheimer’s disease (AD) is a progressive neurodegenerative disease, wherein a progressive loss of cholinergic synapses occurs in hippocampus and neocortex. Decreased concentration of the neurotransmitter, acetylcholine (ACh), appears to be critical element in the development of dementia, and the most appropriate therapeutic approach to treat AD and other form of dementia is to restore acetylcholine levels by inhibiting both major form of cholinesterase: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Consequently, researches have focused their attention towards finding cholinesterase inhibitors from natural products. A large number of such inhibitors have been isolated from medicinal plants. This review presents a comprehensive account of the advances in field of cholinesterase inhibitor phytoconstituents. The structures of some important phytoconstituents (collected through www.Chemspider.com) are also presented and the scope for future research is discussed.
Keywords
Subject
Article metadata
| Title | Cholinesterase inhibitors from botanicals |
|---|---|
| Authors | Faiyaz Ahmed; Raza Murad Ghalib; P. Sasikala; K. K. Mueen Ahmed |
| Affiliations | Indian Institute of Crop Processing Technology, Ministry of Food Processing Industries, Government of India, Thanjavur, INDIA.; Department of Chemistry, Kulliyyah of Science, IIUM, Kuantan, MALAYSIA.; Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, KINGDOM OF SAUDI ARABIA. |
| Corresponding author | faiyazahmed@iicpt.edu.in |
| Journal | Pharmacognosy Reviews |
| Volume / Issue | Vol. 7, Issue 14 |
Also in this issue
- Plants and phytochemicals for Huntington’s diseasepp. 81–91
- Rasayans and non‑rasayans herbs: Future immunodrug – Targetspp. 92–96
- In vitro techniques to assess the proficiency of skin care cosmetic formulationspp. 97–106
- Natural proteins: Sources, isolation, characterization and applicationspp. 107–116
- Thymoquinone in the clinical treatment of cancer: Fact or fiction?pp. 117–120