Original ArticleFree Radicals and AntioxidantsVol. 13 | Issue 1 | pp. 41–45Open access
Cardioprotective Potential of Qusqualis indica Leaves; An in silico Docking Study
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- 3,
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- 1 Department of Pharmacology, Rajiv Academy for Pharmacy, Mathura, Uttar Pradesh, INDIA.
- 2 Department of Pharmaceutical Chemistry, Rajiv Academy for Pharmacy, Mathura, Uttar Pradesh, INDIA.
- 3 Department of Pharmaceutics, Rajiv Academy for Pharmacy, Mathura, Uttar Pradesh, INDIA.
- 4 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Dr. A.P.J. Abdul Kalam University, Lucknow, Uttar Pradesh, INDIA.
- 5 Department of Pharmaceutics, Seth Vishambhar Nath Institute of Pharmacy, Barabanki, Lucknow, Uttar Pradesh, INDIA.
- 6 Department of Pharmacology, Hygia College of Pharmacy, Lucknow, Uttar Pradesh, INDIA.
- 7 Department of Pharmaceutics, Sundeep Pharmacy College, Ghaziabad, Uttar Pradesh, INDIA.
- 8 Department of Pharmaceutics, ABESIT College of Pharmacy, Ghaziabad, Uttar Pradesh, INDIA.
Published in Free Radicals and Antioxidants
Correspondence: Mayank Kulshreshtha
Department of Pharmacology, Rajiv Academy for Pharmacy, Mathura, Uttar Pradesh, INDIA.
Email: professormayank@gmail.com
- Received:
- Mar 14, 2023
- Accepted:
- Apr 2, 2023
- DOI:
- 10.5530/fra.2023.1.7
How to cite
Kulshreshtha, M., Sharma, A. K., Pathak, D., Pandey, P., Snehi, V., Shukla, K. S., Ved, A., Singh, A., Verma, N., Sing, A., & Singh, M. P. Cardioprotective Potential of Qusqualis indica Leaves; An in silico Docking Study. Free Radicals and Antioxidants, 13(1), 41–45. https://doi.org/10.5530/fra.2023.1.7
Abstract
Background: Nowadays cardiac problems are the main cause of death. It includes coronary artery disease, angina pectoris (stable and unstable), congestive heart failure, etc. Objectives: The aim of this paper was to generate scientific data regarding in silico analysis of beta-sitosterol, coumaric acid, lupeol, qurecetin, and urosolic acid of Muscarinic (M2) receptor. Materials and Methods: The leaf powder was treated with different reagents and prepared with different extracts. The phytochemical screening was carried out by treated the extracts with different reagents for the presence of various metabolites. RCSB protein data bank had used for docking studies. Results: The phytochemical screening clearly revealed the presence of various metabolites like flavonoids, alkaloids, saponins, etc. In-silico analysis of beta-sitosterol, coumaric acid, lupeol, qurecetin, and urosolic acid had very good interactions with cholinergic receptor (M2). The obtained score is -7.96, -5.63, -6.7, -7.73, -5.82 for beta-sitosterol, coumaric acid, lupeol, quercetin, and urosolic acid, respectively, which lies in the standard scale. Conclusion: All these metabolites (compounds) are present in Quisqualis indica leaf extracts (aqueous and ethanolic) and found to be good cardio protective agents.
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Article metadata
| Title | Cardioprotective Potential of Qusqualis indica Leaves; An in silico Docking Study |
|---|---|
| Authors | Mayank Kulshreshtha; Anuj Kumar Sharma; Devender Pathak; Pawan Pandey; Varsha Snehi; Karuna Shanker Shukla; Akash Ved; Arpita Singh; Neeraj Verma; Anita Sing; Manjul Pratap Singh |
| Affiliations | Department of Pharmacology, Rajiv Academy for Pharmacy, Mathura, Uttar Pradesh, INDIA.; Department of Pharmaceutical Chemistry, Rajiv Academy for Pharmacy, Mathura, Uttar Pradesh, INDIA.; Department of Pharmaceutics, Rajiv Academy for Pharmacy, Mathura, Uttar Pradesh, INDIA.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Dr. A.P.J. Abdul Kalam University, Lucknow, Uttar Pradesh, INDIA.; Department of Pharmaceutics, Seth Vishambhar Nath Institute of Pharmacy, Barabanki, Lucknow, Uttar Pradesh, INDIA.; Department of Pharmacology, Hygia College of Pharmacy, Lucknow, Uttar Pradesh, INDIA.; Department of Pharmaceutics, Sundeep Pharmacy College, Ghaziabad, Uttar Pradesh, INDIA.; Department of Pharmaceutics, ABESIT College of Pharmacy, Ghaziabad, Uttar Pradesh, INDIA. |
| Corresponding author | professormayank@gmail.com |
| Journal | Free Radicals and Antioxidants |
| Volume / Issue | Vol. 13, Issue 1 |
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