Original ArticleIndian Journal of Natural ProductsVol. 35 | Issue 1 | 2021 | pp. 16–18Open access
Antibacterial Potential of Quercetin against IBD Bacterial Isolates and Cytotoxicity against Colorectal Cancer
- 1,2*,
- 1,
- 1,2
- 1 Department of Natural Product Research, KAHER’s Dr. Prabhakar Kore Basic Science Research Center, KLE Academy of Higher Education and Research, Nehru Nagar, Belagavi, Karnataka, INDIA.
- 2 Department of Pharmaceutics, KAHER’s College of Pharmacy, Belagavi, KLE Academy of Higher Education and Research, Nehru Nagar, Belagavi, Karnataka, INDIA.
Published in Indian Journal of Natural Products
Correspondence: Sanjay Mishra
Department of Natural Product Research, KAHER’s Dr. Prabhakar Kore Basic Science Research Center, KLE Academy of Higher Education and Research, Nehru Nagar, Belagavi, Karnataka, INDIA.; Department of Pharmaceutics, KAHER’s College of Pharmacy, Belagavi, KLE Academy of Higher Education and Research, Nehru Nagar, Belagavi, Karnataka, INDIA.
Email: sanjaymishra@klepharm.edu
Copyright: © 2021 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2021
- DOI:
- 10.5530/ijnp.2021.1.4
How to cite
Mishra, S., Cota, D., & Jalalpure, S. S. (2021). Antibacterial Potential of Quercetin against IBD Bacterial Isolates and Cytotoxicity against Colorectal Cancer. Indian Journal of Natural Products, 35(1), 16–18. https://doi.org/10.5530/ijnp.2021.1.4
Abstract
Background: Quercetin is known for its vast pharmacological activities in recent years. It has shown beneficial effects in animal models of colitis. Purpose: The effectiveness of quercetin in human IBD is limited. Results from these pre-clinical studies indicate an opportunity for developing anti-colitic polyphenol treatments.
Methods: In the present study. Quercetin was evaluated for its antimicrobial potential against clinical isolates of IBD patients (HM95, HM233, HM251, HM615). Cytotoxicity was determined against human colorectal adenocarcinoma cells (Caco2, COLO.205, HT.29), whereas, cytocompatibility against normal rat intestinal epithelial (IEC-6).
Results: It showed an MIC value of 5 mg/mL and MBC value of 10 mg/Ml against all the four bacterial isolates. A dose dependent response was observed against the cell lines.
Conclusion: Antibacterial activity of Quercetin was found against the bacterial isolates from CD and UC patients used in the study. Cytotoxity was observed against colorectal cancer cells with minimal effect on normal cells. However, further investigations are required to understand its precise mechanism.
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Article metadata
| Title | Antibacterial Potential of Quercetin against IBD Bacterial Isolates and Cytotoxicity against Colorectal Cancer |
|---|---|
| Authors | Sanjay Mishra; Damita Cota; Sunil Satyappa Jalalpure |
| Affiliations | Department of Natural Product Research, KAHER’s Dr. Prabhakar Kore Basic Science Research Center, KLE Academy of Higher Education and Research, Nehru Nagar, Belagavi, Karnataka, INDIA.; Department of Pharmaceutics, KAHER’s College of Pharmacy, Belagavi, KLE Academy of Higher Education and Research, Nehru Nagar, Belagavi, Karnataka, INDIA. |
| Corresponding author | sanjaymishra@klepharm.edu |
| Journal | Indian Journal of Natural Products |
| Volume / Issue | Vol. 35, Issue 1 (2021) |
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