Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 56 | Issue 1 | 2022 | pp. 112–120Open access
Preparation and Characterization of Transdermal Therapeutic System Containing Simvastatin: A Statistical Study
- 1,
- 2,
- 3,
- 4,
- 4,
- 4*
- 1 Institute of Technology and Management, GIDA, Gorakhpur, Uttar Pradesh, INDIA.
- 2 Shobhit Institute of Engineering and Technology (Deemed to be University), School of Pharmaceutical Science, Meerut, Uttar Pradesh, INDIA.
- 3 Government College of Pharmacy, Osmanpura, Aurangabad, Maharashtra, INDIA.
- 4 Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, INDIA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Peeyush Bhardwaj
Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, INDIA.
Email: meet2peeyush@gmail.com
Copyright: © 2022 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2022
- Received:
- Aug 6, 2020
- Accepted:
- Jul 28, 2021
- DOI:
- 10.5530/ijper.56.1.14
How to cite
Mishra, S. K., Kumar, R., Patil, P. R., Gupta, R., Mahor, A., & Bhardwaj, P. (2022). Preparation and Characterization of Transdermal Therapeutic System Containing Simvastatin: A Statistical Study. Indian Journal of Pharmaceutical Education and Research, 56(1), 112–120. https://doi.org/10.5530/ijper.56.1.14
Abstract
Introduction: The purpose of the present study was to design, develop, and characterize the transdermal patches containing Simvastatin for the management of blood lipid levels. Materials and Methods: Transdermal patches of Simvastatin were prepared by the solvent casting method. The prepared patches were evaluated for physicochemical characteristics such as thickness, weight variation, folding endurance, percentage moisture uptake, percentage moisture content, percentage drug content, and ex-vivo permeation study. Eudragit polymer grades ERL100 and ERS100 were used in 6:4 and 8:2 ratio to prepare the formulations. Formulations were prepared using 23 factorial designs. Stability studies of the films were subjected to the environmental conditions at a temperature of 45°C, 75% relative humidity for 45 days. Results: The permeation parameters like flux, amount of drug permeated, and permeability coefficient were obtained. It was found that all these values were highest for formulation F8. Conclusion: Based on all parameters, formulation F8 was considered as the best formulation.
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Article metadata
| Title | Preparation and Characterization of Transdermal Therapeutic System Containing Simvastatin: A Statistical Study |
|---|---|
| Authors | Santosh Kumar Mishra; Rahul Kumar; Purushottam Ramchandra Patil; Rishiksh Gupta; Alok Mahor; Peeyush Bhardwaj |
| Affiliations | Institute of Technology and Management, GIDA, Gorakhpur, Uttar Pradesh, INDIA.; Shobhit Institute of Engineering and Technology (Deemed to be University), School of Pharmaceutical Science, Meerut, Uttar Pradesh, INDIA.; Government College of Pharmacy, Osmanpura, Aurangabad, Maharashtra, INDIA.; Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, INDIA. |
| Corresponding author | meet2peeyush@gmail.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 56, Issue 1 (2022) |
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