Area under Curve Method for the Simultaneous Quantitative Estimation of Pravastatin Sodium and Aspirin

In the present study an economic, a precise UV-spectrosphotometric method for estimating Aspirin and Pravastatin sodium in bulk and physical mixture is carried out as there is less paucity of literature on simultaneous estimation of these drugs by area under curve method. 0.1M sodium hydroxide is used as a solvent in the estimation. The method determines Pravastatin sodium and Aspirin at the wavelength range of 292-302 nm and 233-243 nm respectively. Beer’s range was observed at 5-45 μg/mL for Aspirin, 2-18 μg/mL for Pravastatin sodium. 97.91-99.0% for Aspirin and 92.3-99.0% for Pravastatin sodium in the physical mixture are the percentage recoveries. The results observed were statistically validated and ICH guidelines were followed to check the reproducibility of the proposed method via recovery studies. The method may be used for routine analysis of Aspirin and Pravastatin sodium simultaneously at the industrial level and research laboratories in bulk and in their dosage forms.