Review ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 57 | Issue 3 | 2023 | pp. 625–639Open access
Nanosizing Approaches: Current Trends in the Solubility Enhancement of Poorly Water-soluble Drugs
- 1,
- 2,
- 3,
- 4,
- 1,
- 5,
- 6*
- 1 Department of Pharmaceutics, Faculty of Pharmacy, DIT University, Dehradun, Uttarakhand, INDIA.
- 2 Department of Pharmaceutics, B. Pharmacy College, Rampura, Godhra, Gujarat, INDIA.
- 3 Department of Pharmacology, School of Pharmacy, Dr. Vishwanath Karad MIT World Peace University, Pune, Maharashtra, INDIA.
- 4 Department of Pharmaceutical Chemistry, Amity Institute of Pharmacy, Amity University Madhya Pradesh, Gwalior, Madhya Pradesh, INDIA.
- 5 Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Karnataka, INDIA.
- 6 Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, INDIA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Rupshee Jain
Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, INDIA.
Email: rupsheejain@jssuni.edu.in
Copyright: © 2023 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2023
- Received:
- Dec 8, 2022
- Accepted:
- Apr 13, 2023
- DOI:
- 10.5530/ijper.57.3.77
How to cite
Shilpi, S., Gurnany, E., Bhatt, S., Gupta, P. K., Sethiya, N. K., Jain, V., & Jain, R. (2023). Nanosizing Approaches: Current Trends in the Solubility Enhancement of Poorly Water-soluble Drugs. Indian Journal of Pharmaceutical Education and Research, 57(3), 625–639. https://doi.org/10.5530/ijper.57.3.77
Abstract
Nanosuspension formulation and production techniques are currently undergoing remarkable growth in pharmaceutical industries to address poor aqueous solubility and low bioavailability of active pharmaceutical ingredients. It has some distinct character and benefits over other methodologies used to enhance aqueous solubility. The controlled process including formulation and processing variables provide the requisite shape and size of the drug particles in the form of nanosuspension. Generally, drug particles in the form of nanosuspension can be obtained in the size range of 200 to 1000 nm by manipulating various parameters. The pharmacokinetic parameters of the drugs can also be altered by changing the size of drug particles by developing them in the form of nanosuspension. The current review aims to address the physico-chemical characteristics of nanosuspensions, including various formulation considerations. This review also includes potential applications and recent advancements in the field of nanosizing technology.
Keywords
Subject
Article metadata
| Title | Nanosizing Approaches: Current Trends in the Solubility Enhancement of Poorly Water-soluble Drugs |
|---|---|
| Authors | Satish Shilpi; Ekta Gurnany; Shvetank Bhatt; Pawan K Gupta; Neeraj K Sethiya; Vikas Jain; Rupshee Jain |
| Affiliations | Department of Pharmaceutics, Faculty of Pharmacy, DIT University, Dehradun, Uttarakhand, INDIA.; Department of Pharmaceutics, B. Pharmacy College, Rampura, Godhra, Gujarat, INDIA.; Department of Pharmacology, School of Pharmacy, Dr. Vishwanath Karad MIT World Peace University, Pune, Maharashtra, INDIA.; Department of Pharmaceutical Chemistry, Amity Institute of Pharmacy, Amity University Madhya Pradesh, Gwalior, Madhya Pradesh, INDIA.; Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Karnataka, INDIA.; Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, INDIA. |
| Corresponding author | rupsheejain@jssuni.edu.in |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 57, Issue 3 (2023) |
Also in this issue
- Inhalable Microparticulate System for Tuberculosis: An Updated Reviewpp. 640–647
- Advances in in vivo Non-invasive Delivery of Gentamicinpp. 648–657
- Emerging Applications of Electrospun Nanofibers Using Various Fabrication Techniquespp. 658–668
- Mentorship in Pharmacy Schools: Students’ Perspectivepp. 669–677
- 32 Factorial Design of O/W Nanoemulsions of Cholecalciferol Using Box–Behnken Model for Plaque Psoriasispp. 678–683