Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 57 | Issue 3s | 2023 | pp. s814–s820Open access
Chemical Composition and Therapeutic Effects of Ammodicus leucotricus Essential Oils on Neurobehavioral Changes in Wistar Rats after Experimental Scorpion Envenomation
- 1*,
- 2,
- 3,
- 4,
- 5,
- 6,
- 7,
- 8,
- 9
- 1 Laboratory of Pharmacognosy, Bio Toxicology and Biological Valorization of Plants, Moulay Tahar University, Saida, ALGERIA.
- 2 Laboratory of Process, Materials and Environment Engineering, Djillali Liabes University, Sidi-Bel-Abbes, ALGERIA.
- 3 Laboratory of Organic and Macromolecular Physical Chemistry, Djillali Liabes University, Sidi-Bel-Abbes, ALGERIA.
- 4 Laboratory of Applied Organic Synthesis, University of Oran; ALGERIA.
- 5 Centre de Recherche Scientifique et Technique en Analyses Physico-chimiques CRAPC, Bou-Ismail, Tipaza, ALGERIA.
- 6 Faculty of Natural and Life Sciences, Ibn Khaldoun University, BP 14000, Tiaret, ALGERIA.
- 7 University of Caen, ISMRA, LCMT, UMR CNRS 6507, Caen, F-14050, FRANCE.
- 8 Plant Production Department, College of Food and Agriculture Sciences, King Saud University, Riyadh, SAUDI ARABIA.
- 9 Center of Research in Agropastoralisme (CRAPAST), Djelfa, ALGERIA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Ammam Abdelkader
Laboratory of Pharmacognosy, Bio Toxicology and Biological Valorization of Plants, Moulay Tahar University, Saida, ALGERIA.
Email: vetokadi@yahoo.fr
Copyright: © 2023 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2023
- Received:
- Feb 16, 2023
- Accepted:
- Jul 22, 2023
How to cite
Abdelkader, A., Reda, B. A., Redouane, C., Rafik, B., Fouad, B. M., Zemour, H., Villemin, D., Soufan, W., & Belhouadjeb, F. A. (2023). Chemical Composition and Therapeutic Effects of Ammodicus leucotricus Essential Oils on Neurobehavioral Changes in Wistar Rats after Experimental Scorpion Envenomation. Indian Journal of Pharmaceutical Education and Research, 57(3s), s814–s820.
Abstract
Background: Our study consists of a study of the chemical composition of the essential oil administered to a batch of rats undergoing a scorpion sting. Compared with control batches, the nervous state was evaluated by several neurobehavioral tests, namely open classified, dark and light and forced swimming. Materials and Methods: Determination of the composition of the essential oil the plant by GC/MS and its protective effect on the nervous system after exposure of rats to scorpions. Results: of GC/MS show that the chemical composition of this plant is characterized by the dominance of the natural monoterpenoid agent Perilla aldehyde, with a percentage of 70.12%, followed by Limonene (10.10%), Methyleugenol (5.69%), and alpha-Pinene (5.04%). Other compounds such as Perilla alcohol (1.90%), Beta-Pinene (0.61%), Delta-3-Carene (0.59%), Carvone (0.44%) and Camphene (0.33%) were identified only in a small proportion. The series of tests allowed us to see the onset of a depressive state, as well as a significant decrease in locomotor activity in the bitten rats compared to the controls and the treated batch. This hypolocomotor effect is accompanied by a decrease in the animal’s stereotyped behaviours (curiosity, sniffing, biting, and grooming) and muscular tone, which explains the animal’s inability to explore the environment. Conclusion: The neuroprotective power study confirmed the powerful properties of the plant to improve the symptoms caused by the scorpion sting, as proven by several neurobehavioral tests.
Keywords
Article metadata
| Title | Chemical Composition and Therapeutic Effects of Ammodicus leucotricus Essential Oils on Neurobehavioral Changes in Wistar Rats after Experimental Scorpion Envenomation |
|---|---|
| Authors | Ammam Abdelkader; Belmamoun Ahmed Reda; Chadli Redouane; Boudia Rafik; Benhafsa Mekhalef Fouad; Hafidh Zemour; Didier Villemin; Walid Soufan; Fathi Abdellatif Belhouadjeb |
| Affiliations | Laboratory of Pharmacognosy, Bio Toxicology and Biological Valorization of Plants, Moulay Tahar University, Saida, ALGERIA.; Laboratory of Process, Materials and Environment Engineering, Djillali Liabes University, Sidi-Bel-Abbes, ALGERIA.; Laboratory of Organic and Macromolecular Physical Chemistry, Djillali Liabes University, Sidi-Bel-Abbes, ALGERIA.; Laboratory of Applied Organic Synthesis, University of Oran; ALGERIA.; Centre de Recherche Scientifique et Technique en Analyses Physico-chimiques CRAPC, Bou-Ismail, Tipaza, ALGERIA.; Faculty of Natural and Life Sciences, Ibn Khaldoun University, BP 14000, Tiaret, ALGERIA.; University of Caen, ISMRA, LCMT, UMR CNRS 6507, Caen, F-14050, FRANCE.; Plant Production Department, College of Food and Agriculture Sciences, King Saud University, Riyadh, SAUDI ARABIA.; Center of Research in Agropastoralisme (CRAPAST), Djelfa, ALGERIA. |
| Corresponding author | vetokadi@yahoo.fr |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 57, Issue 3s (2023) |
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