Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 57 | Issue 4 | 2023 | pp. 1150–1158Open access
Evaluation of Anti-Depressant Activity of spirulina, a blue-green algae on Chronic Unpredictable Stress Induced Depression in Rats
- 1,
- 2,
- 3,
- 3,
- 3*,
- 4,5*,
- 1,
- 6
- 1 Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.
- 2 Department of Clinical Pharmacology, Clinsync Clinical Research Pvt. Ltd., Telangana, INDIA.
- 3 Department of Pharmaceutics and Pharmacology, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagar, Karnataka, INDIA.
- 4 Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
- 5 Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, Karnataka, INDIA.
- 6 Department of Surgery, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Vakkalagadda Siva Ganesh
Department of Pharmaceutics and Pharmacology, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagar, Karnataka, INDIA.
Correspondence: Sreeharsha Nagaraja
Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, Karnataka, INDIA.
Email: sharsha@kfu.edu.sa
Copyright: © 2023 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2023
- Received:
- Mar 22, 2023
- Accepted:
- Aug 23, 2023
- DOI:
- 10.5530/ijper.57.4.113
How to cite
Basavarajappa, G. M., Balaraju, J., Naveen, N. R., Goudanavar, P., Ganesh, V. S., Nagaraja, S., Shiroorkar, P. N., & Telsang, M. (2023). Evaluation of Anti-Depressant Activity of spirulina, a blue-green algae on Chronic Unpredictable Stress Induced Depression in Rats. Indian Journal of Pharmaceutical Education and Research, 57(4), 1150–1158. https://doi.org/10.5530/ijper.57.4.113
Abstract
Background: Depression is a crippling and pervasive illness that can affect a person in many different ways. It can be identified by certain symptoms, such as modifications in behaviour, psychological functioning, and brain physiology. Materials and Methods: One of the animal models for depression has been the Chronic Unpredictable Mild Stress (CUMS) paradigm. In this study, spirulina algae, which contains tryptophan, was chosen and tested for its anti-depressant effectiveness in the CUS model using Fluoxetine as the gold standard. Wistar rats were chosen to undergo the CUS process for 28 days, and throughout that time, the test drug was given at doses of 400 mg/kg. Results: Behavioural and biochemical parameters were analysed, and has shown significant changes. Conclusion: When compared to the CUS group, spirulina algae at the tested doses had a substantial impact on behavioural and metabolic testing. These findings demonstrated that Spirulina algae specifically exhibited an in vivo anti-depressant-like effect.
Keywords
Subject
Article metadata
| Title | Evaluation of Anti-Depressant Activity of spirulina, a blue-green algae on Chronic Unpredictable Stress Induced Depression in Rats |
|---|---|
| Authors | Girish Meravanige Basavarajappa; Juturu Balaraju; Nimbagal Raghavendra Naveen; Prakash Goudanavar; Vakkalagadda Siva Ganesh; Sreeharsha Nagaraja; Predeepkumar Narayanappa Shiroorkar; Mallikarjun Telsang |
| Affiliations | Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Clinical Pharmacology, Clinsync Clinical Research Pvt. Ltd., Telangana, INDIA.; Department of Pharmaceutics and Pharmacology, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagar, Karnataka, INDIA.; Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, Karnataka, INDIA.; Department of Surgery, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA. |
| Corresponding author | sharsha@kfu.edu.sa |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 57, Issue 4 (2023) |
Also in this issue
- Sustainable Antimicrobial Nanomaterials: A Promising Treatment for Multiple Drug Resistant Microorganismspp. 937–950
- Role of Stem Cells in the Management of Type-I Diabetes Mellituspp. 951–955
- Biotherapeutic Potential of Lactobacillus Probiotic Strains on Streptococcus mutans Biofilm in Dental Caries-Pathogenesis Revisitedpp. 956–964
- Quality by Design based Quercetin Hydrate Nanoemulsions for Enhanced Solubility by Reducing Particle Sizepp. 965–970
- Mucoadhesive Chitosan-Coated PLGA Nanoparticles of Ashwagandha Extract for Colon-Targeted Deliverypp. 971–982